| Type |
Article |
| Date |
2010-12 |
| Language |
English |
| Author(s) |
Munschy Catherine1, Moisan Karine1, Tixier Celine1, Pacepavicius G.2, Alaee M.2 |
| Affiliation(s) |
1 : Inst Francais Rech Exploitat Mer IFREMER, Lab Biogeochem Organ Contaminants, F-44311 Nantes 3, France.
2 : Environm Canada, Aquat Ecosyst Protect Res Div, Burlington, ON L7R 4A6, Canada. |
| Source |
Environmental Pollution (0269-7491) (Elsevier Sci Ltd), 2010-12 , Vol. 158 , N. 12 , P. 3527-3533 |
| DOI |
10.1016/j.envpol.2010.08.021 |
| WOS© Times Cited |
20 |
| Keyword(s) |
Marine flatfish, PBDEs, Bioaccumulation, Biotransformation, Hydroxylated metabolites |
| Abstract |
The uptake, elimination and transformation of six PBDE congeners (BDE-28, -47, -99, -100, -153, -209) were studied in juvenile common sole (Solea solea L) exposed to spiked contaminated food over a three-month period, and then depurated over a five-month period. Methoxylated (MeO-) and hydroxylated (OH-) PBDEs were determined in fish plasma exposed to PBDEs and compared to those obtained in control fish. While all MeO- and some OH- congeners identified in fish plasma were found to originate from non-metabolic sources, several OH- congeners, i.e., OH-tetraBDEs and OH-pentaBDEs, were found to originate from fish metabolism. Among these, 4 '-OH-BDE-49 was identified as a BDE-47 metabolite. Congener 4 '-OH-BDE-101, identified here for the first time, may be the result of BDE-99 metabolic transformation. Our results unequivocally showed that PBDEs are metabolised in juvenile sole via the formation of OH- metabolites. However, this was not a major biotransformation route compared to biotransformation through debromination. (C) 2010 Elsevier Ltd. All rights reserved. |
| Full Text |
| File |
Pages |
Size |
Access |
|
7 |
289 KB |
Access on demand |
| Author's final draft |
33 |
109 KB |
Open access |
|
