FN Archimer Export Format
PT J
TI Exposures of zebrafish through diet to three environmentally relevant mixtures of PAHs produce behavioral disruptions in unexposed F1 and F2 descendant
BT 
AF VIGNET, Caroline
   JOASSARD, Lucette
   LYPHOUT, Laura
   GUIONNET, Tiphaine
   GOUBEAU, Manon
   LE MENACH, Karyn
   BRION, Francois
   KAH, Olivier
   CHUNG, Bon-Chu
   BUDZINSKI, Helene
   BEGOUT, Marie-Laure
   COUSIN, Xavier
AS 1:1;2:2;3:2;4:2;5:1;6:3;7:4;8:5;9:6;10:3;11:2;12:1,7;
FF 1:PDG-RBE-BE;2:PDG-RBE-HGS-LRHLR;3:;4:;5:;6:;7:;8:;9:;10:;11:PDG-RBE-HGS-LRHLR;12:;
C1 IFREMER, Ecotoxicol Lab, F-17137 Lhoumeau, France.
   IFREMER, Fisheries Lab, F-17137 Lhoumeau, France.
   Univ Bordeaux 1, EPOC, UMR CNRS 5805, F-33405 Talence, France.
   INERIS, Direct Risques Chron, Unite Ecotoxicol Vitro & Vivo, F-60550 Verneuil En Halatte, France.
   Univ Rennes 1, Team NEED, Res Inst Hlth Environm & Occupat, INSERM U1085,Case 1302, F-35042 Rennes, France.
   Acad Sinica, Inst Mol Biol, Taipei, Taiwan.
   INRA LPGP, F-35042 Rennes, France.
C2 IFREMER, FRANCE
   IFREMER, FRANCE
   UNIV BORDEAUX, FRANCE
   INERIS, FRANCE
   UNIV RENNES, FRANCE
   ACAD SINICA, TAIWAN
   INRA, FRANCE
SI LA ROCHELLE
SE PDG-RBE-BE
   PDG-RBE-HGS-LRHLR
IN WOS Ifremer jusqu'en 2018
   copubli-france
   copubli-p187
   copubli-univ-france
   copubli-int-hors-europe
IF 2.76
TC 26
UR https://archimer.ifremer.fr/doc/00259/37030/35688.pdf
LA English
DT Article
DE ;Danio rerio;Polycyclic aromatic hydrocarbon;Offspring;Transgenerational effect;Heavy oil;Light crude oil;Locomotor activity;Photomotor response;Anxiety-like behavior
AB The release of polycyclic aromatic hydrocarbons (PAHs) into the environment has increased very substantially over the last decades. PAHs are hydrophobic molecules which can accumulate in high concentrations in sediments acting then as major secondary sources. Fish contamination can occur through contact or residence nearby sediments or though dietary exposure. In this study, we analyzed certain physiological traits in unexposed fish (F1) issued from parents (F0) exposed through diet to three PAH mixtures at similar and environmentally relevant concentrations but differing in their compositions. For each mixture, no morphological differences were observed between concentrations. An increase in locomotor activity was observed in larvae issued from fish exposed to the highest concentration of a pyrolytic (PY) mixture. On the contrary, a decrease in locomotor activity was observed in larvae issued from heavy oil mixture (HO). In the case of the third mixture, light oil (LO), a reduction of the diurnal activity was observed during the setup of larval activity. Behavioral disruptions persisted in F1-PY juveniles and in their offspring (F2). Endocrine disruption was analyzed using cyp19a1b:GFP transgenic line and revealed disruptions in PY and LO offspring. Since no PAH metabolites were dosed in larvae, these findings suggest possible underlying mechanisms such as altered parental signaling molecule and/or hormone transferred in the gametes, eventually leading to early imprinting. Taken together, these results indicate that physiological disruptions are observed in offspring of fish exposed to PAH mixtures through diet.
PY 2015
PD NOV
SO Environmental Science And Pollution Research
SN 0944-1344
PU Springer Heidelberg
VL 22
IS 21
UT 000363964700012
BP 16371
EP 16383
DI 10.1007/s11356-015-4157-8
ID 37030
ER

EF