FN Archimer Export Format
PT J
TI Norwalk virus-specific binding to oyster digestive tissues
BT 
AF LE GUYADER, Soizick
   LOISY, Fabienne
   ATMAR, R
   HUTSON, A
   ESTES, M
   RUVOEN-CLOUET, N
   POMMEPUY, Monique
   LE PENDU, J
AS 1:1;2:1;3:2;4:2;5:2;6:3,4,5;7:1;8:4,5;
FF 1:PDG-DOP-DCN-EMP-MIC;2:PDG-DOP-DCN-EMP-MIC;3:;4:;5:;6:;7:PDG-DOP-DCN-EMP;8:;
C1 IFREMER, F-44311 Nantes 3, France.
   Baylor Coll Med, Houston, TX 77030 USA.
   Ecole Natl Vet, Nantes, France.
   Inst Natl Sante & Rech Med, Nantes, France.
   Univ Nantes, F-44035 Nantes, France.
C2 IFREMER, FRANCE
   BAYLOR COLL MED, USA
   ECOLE NATL VET, FRANCE
   INSERM, FRANCE
   UNIV NANTES, FRANCE
SI NANTES
   BREST
SE PDG-DOP-DCN-EMP-MIC
   PDG-DOP-DCN-EMP
IN WOS Ifremer jusqu'en 2018
   copubli-france
   copubli-univ-france
   copubli-int-hors-europe
IF 5.094
TC 184
UR https://archimer.ifremer.fr/doc/2006/publication-1542.pdf
LA English
DT Article
DE ;Bioaccumulation;Shellfish;Escherichia coli;Pathogen;Oyster digestive tissue;Noroviruses
AB The primary pathogens related to shellfishborne gastroenteritis outbreaks are noroviruses. These viruses show persistence in oysters, which suggests an active mechanism of virus concentration. We investigated whether Norwalk virus or viruslike particles bind specifically to oyster tissues after bioaccumulation or addition to tissue sections. Since noroviruses attach to carbohydrates of the histo-blood group family, tests using immunohistochemical analysis were performed to evaluate specific binding of virus or viruslike particles to oyster tissues through these ligands. Viral particles bind specifically to digestive ducts (midgut, main and secondary ducts, and tubules) by carbohydrate structures with a terminal N-acetylgalactosamine residue in an alpha linkage (same binding site used for recognition of human histo-blood group antigens). These data show that the oyster can selectively concentrate a human pathogen and that conventional depuration will not eliminate noroviruses from oyster tissue.
PY 2006
PD JUL
SO Emerging infectious diseases
SN 1080-6040
PU CDC
VL 12
IS 6
UT 000237829900008
BP 931
EP 936
ID 1542
ER

EF