FN Archimer Export Format
PT J
TI Local mutagenic impact of insertions of LTR retrotransposons on the mouse genome
BT 
AF DESMARAIS, Erick
   BELKHIR, Khalid
   GARZA, John Carlos
   BONHOMME, Francois
AS 1:1;2:1;3:2;4:1,3,4;
FF 1:;2:;3:;4:;
C1 Univ Montpellier 2, CNRS, IFREMER, Lab Genome Populat Interact Adaptat,UMR5171, F-34095 Montpellier, France.
   SW Fisheries Sci Ctr, Santa Cruz, CA 95060 USA.
C2 UNIV MONTPELLIER, FRANCE
   NOAA, USA
   IFREMER, FRANCE
   CNRS, FRANCE
SI MONTPELLIER
SE PDG-DOP-DCM-BOME-LALR
IN WOS Ifremer jusqu'en 2018
   copubli-france
   copubli-univ-france
   copubli-int-hors-europe
IF 2.767
TC 0
UR https://archimer.ifremer.fr/doc/2006/publication-2091.pdf
LA English
DT Article
DE ;RMER10;Simple tandem repeats;LTR retrotransposons;Mouse genome
AB Solitary LTR loci are the predominant form of LTR retrotransposons in most eukaryotic genomes. They originate from recombination between the two LTRs of an ancestral retrovirus and are therefore incapable of transposition. Despite this inactivity, they appear to have a substantial impact on the host genome. Here we use the murine RMER10 LTR family as an example to describe how such elements can reshape regions of the genome through multiple mutations on an evolutionary time scale. Specifically, we use phylogenetic analysis of multiple copies of RMER10 in rodent species, as well as comparisons of orthologous pairs in mouse and rat, to argue that insertions of members of this family have locally induced the emergence of tandem repeat loci as well as many indels. Analysis of structural aspects of these sequences (secondary structures and transcription factors signals) may explain why RMER10 can become endogenous "mutagenic" factors through induction of replication fork blockages and/or error-prone repair of aberrant DNA structures. This hypothesis is also consistent with features of other interspersed repeated elements.
PY 2006
PD NOV
SO Journal of Molecular Evolution
SN 0022-2844
PU Springer
VL 63
IS 5
UT 000242014800008
BP 662
EP 675
DI 10.1007/s00239-005-0301-2
ID 2091
ER

EF