FN Archimer Export Format
PT J
TI First evidence of the activation of Cg-timp, an immune response component of pacific oysters, through a damage-associated molecular pattern pathway
BT 
AF MONTAGNANI, Caroline
   AVARRE, Jean-Christophe
   DE LORGERIL, Julien
   QUIQUAND, M
   BOULO, Viviane
   ESCOUBAS, Jean-Michel
AS 1:1;2:2;3:2;4:2;5:2;6:3;
FF 1:PDG-DOP-DCOP-AQUAPOL-LBQP;2:PDG-DRV-RA-DRIM;3:PDG-DOP-DCM-BOME-LALR;4:;5:PDG-DOP-DCM-BOME-LALR;6:;
C1 Univ Montpellier 2, INRA, Ecol Microbienne Insectes & Interact Hote Pathoge, UMR 1133, F-34095 Montpellier, France.
   IFREMER, Taravao 98719, Tahiti, Fr Polynesia.
   Lab Symbioses Trop & Mediterraneennes, UMR113, F-34398 Montpellier, France.
C2 UNIV MONTPELLIER, FRANCE
   IFREMER, FRANCE
   LSTM, FRANCE
SI TAHITI
   MONTPELLIER
SE PDG-DOP-DCOP-AQUAPOL-LBQP
   PDG-DRV-RA-DRIM
   PDG-DOP-DCM-BOME-LALR
   PDG-DOP-DCN-AGSAE-GPIA
IN WOS Ifremer jusqu'en 2018
   copubli-france
   copubli-univ-france
IF 3.155
TC 33
UR https://archimer.ifremer.fr/doc/2007/publication-2094.pdf
LA English
DT Article
DE ;Damage associated molecular pattern;Tissue inhibitor of metalloproteinase;Metalloproteinase;Mollusk immunity;Crassostrea gigas;Oyster
AB In a previous work, we characterized a Crassostrea gigas cPNA (Cg-timp) encoding a protein which presents all the features of vertebrate tissue inhibitor of metalloproteinase (TIMP). The expression pattern of this gene led us to propose that Cg-timp is an important factor in oyster wound heating and defense mechanisms. Here we describe the analysis of Cg-timp expression in oysters challenged by live or dead bacteria as well as by bacterial secretory/excretory products and metalloproteinase. Surprisingly, bacterial secretory/excretory products activate Cg-timp gene expression whereas heat-inactivated ones do not. To address the question of the signal transduction pathway involved in Cg-timp gene activation, we isolated and sequenced Cg-timp promoter and upstream region. A 1-kb genomic DNA fragment flanking the 5'-end of the gene contains several regulatory elements and notably three NF-kappa B binding sites. The potential involvement of these motifs in Cg-timp gene regulation is discussed. (c) 2006 Elsevier Ltd. All rights reserved.
PY 2007
SO Developmental & Comparative Immunology
SN 0145-305X
PU Elsevier
VL 31
IS 1
UT 000242124600001
BP 1
EP 11
DI 10.1016/j.dci.2006.04.002
ID 2094
ER

EF