Fucoidan a sulfated polysaccharide from brown algae is a potent modulator of connective tissue proteolysis
|Author(s)||Senni Karim1, Gueniche Farida1, Foucault Bertaud Alexandrine1, Igondjo Tchen Sylvie1, Fioretti Florence1, Colliec-Jouault Sylvia2, Durand Patrick2, Guezennec Jean2, Godeau Gaston1, Letourneur Didier3, 4|
|Affiliation(s)||1 : Univ Paris Descartes, Fac Chirurg Dentaire, EA2496, Montrouge, France.
2 : IFREMER, Nantes, France.
3 : Univ Paris 07, INSERM, U698, CHU X Bichat, Paris, France.
4 : Univ Paris 13, INSERM, U698, CHU X Bichat, Paris, France.
|Source||Archives of Biochemistry and Biophysics (0003-9861) (Elsevier), 2006 , Vol. 445 , N. 1 , P. 56-64|
|WOS© Times Cited||85|
|Keyword(s)||Interleukin 1 beta, Leukocyte elastase, Matrix metalloproteinases, Extracellular matrix remodeling, Glycosaminoglycans, Fucoidan|
|Abstract||Fucoidans are sulfated fucosylated polymers from brown algae cell wall that exhibit some heparin/heparan sulfate properties. We previously demonstrated that these polysaccharides were able in vitro to stimulate dermal fibroblast proliferation and extracellular matrix deposition. Here, we investigated the action of a 16 kDa fucoidan fraction on parameters involved in connective tissue breakdown. This fucoidan is able to inhibit gelatinase A secretion and stromelysin 1 induction by interleukin-1 beta on dermal fibroblasts in culture. Furthermore, we observed that fucoidan increases the rate of association of MMPs with their specific inhibitors namely TIMPs. Using tissue sections of human skin in ex vivo experiments, we evidenced that this polysaccharide was able to minimize human leukocyte elastase activity resulting in the protection of human skin elastic fiber network against the enzymatic proteolysis due to this serine proteinase. These results suggested that fucoidan could be used for treating some inflammatory pathologies in which uncontrolled extracellular matrix degradation takes place. (c) 2005 Elsevier Inc. All rights reserved.|