FN Archimer Export Format
PT J
TI Fucoidan a sulfated polysaccharide from brown algae is a potent modulator of connective tissue proteolysis
BT 
AF SENNI, Karim
   GUENICHE, Farida
   FOUCAULT BERTAUD, Alexandrine
   IGONDJO TCHEN, Sylvie
   FIORETTI, Florence
   COLLIEC-JOUAULT, Sylvia
   DURAND, Patrick
   GUEZENNEC, Jean
   GODEAU, Gaston
   LETOURNEUR, Didier
AS 1:1;2:1;3:1;4:1;5:1;6:2;7:2;8:2;9:1;10:3,4;
FF 1:;2:;3:;4:;5:;6:PDG-DOP-DCB-BM-BMM;7:PDG-DOP-DCB-BM;8:PDG-DOP-DCB-BM-BMM;9:;10:;
C1 Univ Paris Descartes, Fac Chirurg Dentaire, EA2496, Montrouge, France.
   IFREMER, Nantes, France.
   Univ Paris 07, INSERM, U698, CHU X Bichat, Paris, France.
   Univ Paris 13, INSERM, U698, CHU X Bichat, Paris, France.
C2 UNIV PARIS 05, FRANCE
   IFREMER, FRANCE
   UNIV PARIS 07, FRANCE
   UNIV PARIS 13, FRANCE
SI NANTES
   BREST
SE PDG-DOP-DCB-BM-BMM
   PDG-DOP-DCB-BM
IN WOS Ifremer jusqu'en 2018
   copubli-france
   copubli-univ-france
IF 2.969
TC 95
UR https://archimer.ifremer.fr/doc/2006/publication-2147.pdf
LA English
DT Article
DE ;Interleukin 1 beta;Leukocyte elastase;Matrix metalloproteinases;Extracellular matrix remodeling;Glycosaminoglycans;Fucoidan
AB Fucoidans are sulfated fucosylated polymers from brown algae cell wall that exhibit some heparin/heparan sulfate properties. We previously demonstrated that these polysaccharides were able in vitro to stimulate dermal fibroblast proliferation and extracellular matrix deposition. Here, we investigated the action of a 16 kDa fucoidan fraction on parameters involved in connective tissue breakdown. This fucoidan is able to inhibit gelatinase A secretion and stromelysin 1 induction by interleukin-1 beta on dermal fibroblasts in culture. Furthermore, we observed that fucoidan increases the rate of association of MMPs with their specific inhibitors namely TIMPs. Using tissue sections of human skin in ex vivo experiments, we evidenced that this polysaccharide was able to minimize human leukocyte elastase activity resulting in the protection of human skin elastic fiber network against the enzymatic proteolysis due to this serine proteinase. These results suggested that fucoidan could be used for treating some inflammatory pathologies in which uncontrolled extracellular matrix degradation takes place. (c) 2005 Elsevier Inc. All rights reserved.
PY 2006
SO Archives of Biochemistry and Biophysics
SN 0003-9861
PU Elsevier
VL 445
IS 1
UT 000234635500007
BP 56
EP 64
DI 10.1016/j.abb.2005.11.001
ID 2147
ER

EF