FN Archimer Export Format PT J TI Impact of diuron on aneuploidy and hemocyte parameters in Pacific oyster, Crassostrea gigas BT AF BOUILLY, Karine BONNARD, Marc GAGNAIRE, Beatrice RENAULT, Tristan LAPEGUE, Sylvie AS 1:1;2:1;3:1;4:1;5:1; FF 1:PDG-DOP-DCN-AGSAE-LGP;2:PDG-DOP-DCN-AGSAE-LGP;3:PDG-DOP-DCN-AGSAE-LGP;4:PDG-DOP-DCN-AGSAE-LGP;5:PDG-DOP-DCN-AGSAE-LGP; C1 IFREMER, Lab Genet & Pathol, F-17390 La Tremblade, France. C2 IFREMER, FRANCE SI LA TREMBLADE SE PDG-DOP-DCN-AGSAE-LGP IN WOS Ifremer jusqu'en 2018 IF 1.62 TC 41 UR https://archimer.ifremer.fr/doc/2007/publication-2178.pdf LA English DT Article DE ;Diuron;Herbicide impact;Cytometry;Hemocyte;Aneuploidy;Crassostrea gigas AB Diuron is a substituted urea herbicide used for agricultural and nonagricultural weed control. Its widespread use and relatively slow breakdown led us to analyze its influence on aneuploidy level (lowered chromosome number in a percentage of somatic cells) and hemocyte parameters in Pacific oysters, Crassostrea gigas. Adult oysters were subjected to two diuron concentrations (300 ng L-1 and 3 mu g L-1) for 11 weeks. Significantly higher aneuploidy level was observed in diuron-treated oysters compared with the control. Furthermore, the observed impact on aneuploidy persisted to the next generation as offspring exhibited significantly higher aneuploidy levels when their parents had been exposed to diuron. Significant increases in hemocyte parameters (cell mortality, phagocytosis, granulocyte percentage, reactive oxygen species, and lysosome presence) of the adults were also observed after 4 weeks of diuron exposure. The effects observed on oyster aneuploidy level and hemocyte parameters could have PY 2007 SO Archives of Environmental Contamination and Toxicology SN 0090-4341 PU Springer VL 52 IS 1 UT 000242623800008 BP 58 EP 63 DI 10.1007/s00244-005-0256-8 ID 2178 ER EF