FN Archimer Export Format
PT J
TI Toxicity assessment of peptaibols and contaminated sediments on Crassostrea gigas embryos
BT 
AF POIRIER, Laurence
   QUINIOU, Francoise
   RUIZ, Nicolas
   MONTAGU, Monique
   AMIARD, Jean-Claude
   POUCHUS, Yves François
AS 1:1;2:2;3:1;4:1;5:1;6:1;
FF 1:;2:PDG-DOP-DCN-BE-LBEX;3:;4:;5:;6:;
C1 Univ Nantes, SMAB EA2160, Fac Pharm, F-44000 Nantes, France.
   IFREMER, Ctr Brest, BE EX, F-29280 Plouzane, France.
C2 UNIV NANTES, FRANCE
   IFREMER, FRANCE
SI BREST
SE PDG-DOP-DCN-BE-LBEX
IN WOS Ifremer jusqu'en 2018
   copubli-france
   copubli-univ-france
IF 2.975
TC 21
UR https://archimer.ifremer.fr/doc/2007/publication-2680.pdf
LA English
DT Article
DE ;Risk assessment;Embryotoxicity;Bivalve bioassay;Mycotoxins;Marine fungi
AB Peptaibols are known membrane-modifying peptides that were recently detected in marine sediments and mussels collected from a shellfish farming area (Fier d'Ars, Atlantic coast, France). In this investigation, embryotoxicity bioassays with oysters (Crassostrea gigas) were performed to assess acute toxicity of alamethicin and different groups of peptaibols produced by a Trichoderma longibrachiatum strain isolated from marine environment. C gigas embryos appeared very sensitive to all the metabolites examined with higher toxic effects for long-sequence peptides (EC50 ranging from 10 to 64nM). D-shaped larvae with mantle abnormality were particularly noticed when peptaibol concentrations increased. Disturbances of embryogenesis were also observed following exposure to organic and aqueous extract of sediments from Fier d'Ars (EC50 = 42.4 and 6.6 g L-1 dry weight, respectively). Although peptaibol concentrations measured in these sediments could explain only a part of the toxic effects observed, this study suggests that these mycotoxins can induce larval abnormalities in a population of exposed animals at environmentally realistic concentrations. Their detection in coastal areas devoted to bivalve culture should be taken into account. (c) 2007 Elsevier B.V. All rights reserved.
PY 2007
PD AUG
SO Aquatic Toxicology
SN 0166-445X
PU Elsevier
VL 83
IS 4
UT 000248471100002
BP 254
EP 262
DI 10.1016/j.aquatox.2007.04.009
ID 2680
ER

EF