FN Archimer Export Format
PT J
TI In vitro research of anti-HSV-1 activity in different extracts from Pacific oysters Crassostrea gigas
BT 
AF OLICARD, Cecile
   DIDIER, Yohann
   MARTY, Christel
   BOURGOUGNON, Nathalie
   RENAULT, Tristan
AS 1:1,2,3;2:1;3:2;4:2;5:1;
FF 1:;2:PDG-DOP-DCN-AGSAE-LGP;3:;4:;5:PDG-DOP-DCN-AGSAE-LGP;
C1 IFREMER, Lab Genet & Pathol, F-17390 La Tremblade, France.
   Univ Bretagne Sud, Lab Biotechnol & Chim Marines, EA 2594, Ctr Rech Yves Coppens, F-56017 Vannes, France.
   Univ La Rochelle, Lab Biol & Environm Marins, F-17042 La Rochelle, France.
C2 IFREMER, FRANCE
   UBS, FRANCE
   UNIV LA ROCHELLE, FRANCE
SI LA TREMBLADE
SE PDG-DOP-DCN-AGSAE-LGP
IN WOS Ifremer jusqu'en 2018
   copubli-france
   copubli-univ-france
IF 1.361
TC 29
UR https://archimer.ifremer.fr/doc/2005/publication-2922.pdf
LA English
DT Article
DE ;Haemolymph;Antiviral peptides;HSV 1;OsHV 1;Antiviral defence;Crassostrea gigas;Oyster
AB Mortalities related to the detection of Ostreid Herpesvirus 1 (OsHV-1) have been previously reported in France among larvae and spat of the Pacific oyster Crassostrea gigas. Adult oysters appear less sensitive to herpesvirus infections, although OsHV-1 has been detected in adults without signs of disease or mortality. This suggests that the virus is able to persist in its host and that adult oysters may be able to control OsHV-1 infection. Little is known about antiviral substances in invertebrates. The present work concerns the research of antiviral substances in adult oyster C. gigas, where putative antiviral activities were monitored using 3 strategies: (1) in metabolites with variable polarity, (2) in peptidic extracts and (3) in crude haemolymph. In vitro antiviral assays were based on inhibition of Herpes simplex virus type 1 (HSV-1) replication in Vero cell monolayers. All extracts presented no cytotoxicity. Antiviral activity was detected in the fresh filtered haemolymph (EC50:425 mu g ml(-1)) and seasonal variation of the haemolymph antiviral activity was monitored.
PY 2005
PD NOV
SO Diseases of aquatic organisms
SN 0177-5103
PU Inter-Research
VL 67
IS 1-2
UT 000234935200020
BP 141
EP 147
ID 2922
ER

EF