|Author(s)||Mitta Guillaume, Vandenbulcke Franck, Noel Thierry, Romestand Bernard, Beauvillain Jean Claude, Salzet Michel, Roch Philippe|
|Affiliation(s)||Univ Montpellier 2, CNRS, IFREMER, F-34095 Montpellier, France.
Univ Sci & Tech Lille Flandres Artois, CNRS, UPRES A 8017, Grp Neuroimmun Hirudinees,Lab Endocrinol Annelide, F-59655 Villeneuve Dascq, France.
INSERM, Unite 422, F-59045 Lille, France.
|Source||Journal of Cell Science (0021-9533) (Company of Biologists), 2000-08 , Vol. 113 , N. 15 , P. 2759-2769|
|WOS© Times Cited||100|
|Keyword(s)||Innate immunity, Hemocyte, Mussel, Myticin, Mytilin, Defensin, Antimicrobial|
|Abstract||In previous papers, we characterised 3 types of 4-kDa, cysteine-rich, cationic antimicrobial peptides: MGDs (for Mytilus galloprovincialis defensins), mytilins and myticins, which are abundant in the mussel hemocytes. In the present work, me revealed a differential distribution of the cells expressing the different genes. In addition, using confocal and electron microscopy, we confirmed that defensins and mytilins were partially located in different sub-types of circulating hemocytes although the peptides can be located in the same cell, and even in the same granule. We also demonstrated that mytilins exert their microbicidal effect within the cells through the process of phagosome-mytilin granule fusion leading to the co-location of ingested bacteria and mytilins.|
Mitta Guillaume, Vandenbulcke Franck, Noel Thierry, Romestand Bernard, Beauvillain Jean Claude, Salzet Michel, Roch Philippe (2000). Differential distribution and defence involvement of antimicrobial peptides in mussel. Journal of Cell Science, 113(15), 2759-2769. Open Access version : https://archimer.ifremer.fr/doc/00000/413/