FN Archimer Export Format
PT J
TI Differential distribution and defence involvement of antimicrobial peptides in mussel
BT 
AF MITTA, Guillaume
   VANDENBULCKE, Franck
   NOEL, Thierry
   ROMESTAND, Bernard
   BEAUVILLAIN, Jean Claude
   SALZET, Michel
   ROCH, Philippe
AS 1:;2:;3:;4:;5:;6:;7:;
FF 1:PDG-DRV-RA-DRIM;2:;3:PDG-DRV-RA-DRIM;4:;5:;6:;7:;
C1 Univ Montpellier 2, CNRS, IFREMER, F-34095 Montpellier, France.
   Univ Sci & Tech Lille Flandres Artois, CNRS, UPRES A 8017, Grp Neuroimmun Hirudinees,Lab Endocrinol Annelide, F-59655 Villeneuve Dascq, France.
   INSERM, Unite 422, F-59045 Lille, France.
C2 UNIV MONTPELLIER 2, FRANCE
   UNIV SCI & TECH LILLE FLANDRES ARTOIS, FRANCE
   INSERM, FRANCE
SI MONTPELLIER
SE PDG-DRV-RA-DRIM
IN WOS Ifremer jusqu'en 2018
   copubli-univ-france
IF 5.996
TC 109
UR https://archimer.ifremer.fr/doc/2000/publication-413.pdf
LA English
DT Article
DE ;Innate immunity;Hemocyte;Mussel;Myticin;Mytilin;Defensin;Antimicrobial
AB In previous papers, we characterised 3 types of 4-kDa, cysteine-rich, cationic antimicrobial peptides: MGDs (for Mytilus galloprovincialis defensins), mytilins and myticins, which are abundant in the mussel hemocytes. In the present work, me revealed a differential distribution of the cells expressing the different genes. In addition, using confocal and electron microscopy, we confirmed that defensins and mytilins were partially located in different sub-types of circulating hemocytes although the peptides can be located in the same cell, and even in the same granule. We also demonstrated that mytilins exert their microbicidal effect within the cells through the process of phagosome-mytilin granule fusion leading to the co-location of ingested bacteria and mytilins.
PY 2000
PD AUG
SO Journal of Cell Science
SN 0021-9533
PU Company of Biologists
VL 113
IS 15
UT 000088830800013
BP 2759
EP 2769
ID 413
ER

EF