FN Archimer Export Format
PT J
TI Cloning and retinal expression of melatonin receptors in the European sea bass, Dicentrarchus labrax
BT 
AF SAUZET, S
   BESSEAU, L
   PEREZ, P
   COVES, Denis
   CHATAIN, Beatrice
   PEYRIC, E
   BOEUF, G
   MUNOZ CUETO, J
   FALCON, J
AS 1:1,2;2:1,2;3:3;4:4;5:4;6:1,2;7:1,2;8:3;9:1,2;
FF 1:;2:;3:;4:PDG-DOP-DCM-BOME-LALR;5:PDG-DOP-DCM-BOME-LALR;6:;7:;8:;9:;
C1 Univ Paris 06, UMR7628, Lab Arago, F-66651 Banyuls Sur Mer, France.
   CNRS, UMR7628 & GDR2821, F-66651 Banyuls Sur Mer, France.
   Univ Cadiz, Fac Ciencias Mar & Ambientales, Dept Biol, E-11510 Puerto Real, Spain.
   IFREMER CNRS, GDR2821, Lab Aquaculture Languedoc Roussillon, Stn Aquaculture Expt, F-34250 Palavas Les Flots, France.
C2 UNIV PARIS 06, FRANCE
   CNRS, FRANCE
   UNIV CADIZ, SPAIN
   IFREMER, FRANCE
SI PALAVAS
SE PDG-DOP-DCM-BOME-LALR
IN WOS Ifremer jusqu'en 2018
   copubli-france
   copubli-europe
   copubli-univ-france
IF 2.654
TC 51
UR https://archimer.ifremer.fr/doc/2008/publication-4513.pdf
LA English
DT Article
DE ;Retina;Melatonin receptors;Sea bass
AB Melatonin contributes to synchronizing behaviors and physiological functions to daily and seasonal rhythm in fish. However, no coherent vision emerges because the effects vary with the species, sex, moment of the year or sexual cycle. And, scarce information is available concerning the melatonin age, receptors, which is crucial to our understanding of the role melatonin plays. We report here the full length cloning of three different melatonin receptor subtypes in the sea bass Dicentrarchus labrax, belonging, respectively, to the MT1, MT2 and Mellc subtypes. MT1, the most abundantly expressed, was detected in the central nervous system, retina, and gills. MT2 was detected in the pituitary gland, blood cells and, to a lesser extend, in the optic tectum, diencephalon, liver and retina. Mel1c was mainly expressed in the skin; traces were found in the retina. The cellular sites of MT1 and MT2 expressions were investigated by in situ hybridization in the retina of pigmented and albino fish. The strongest signals were obtained with the MT1 riboprobes. Expression was seen in cells also known to express the enzymes of the melatonin biosynthesis, i.e., in the photoreceptor, inner nuclear and ganglion cell layers. MT1 receptor mRNAs were also abundant in the retinal pigment epithelium. The results are consistent with the idea that melatonin is an autocrine (neural retina) and paracrine (retinal pigment epithelium) regulator of retinal function. The molecular tools provided here will be of valuable interest to further investigate the targets and role of melatonin in nervous and peripheral tissues of fish. (c) 2008 Published by Elsevier Inc.
PY 2008
PD JUL
SO General and Comparative Endocrinology
SN 0016-6480
PU Elsevier
VL 157
IS 2
UT 000257087000012
BP 186
EP 195
DI 10.1016/j.ygcen.2008.04.008
ID 4513
ER

EF