A relationship between antimicrobial peptide gene expression and capacity of a selected shrimp line to survive a Vibrio infection

Type Article
Date 2008-07
Language English
Author(s) de Lorgeril JulienORCID1, 2, Gueguen YannickORCID1, Goarant Cyrille2, Goyard Emmanuel2, Mugnier Chantal2, Fievet Julie1, Piquemal D3, Bachere Evelyne1
Affiliation(s) 1 : Univ Montpellier 2, CNRS, IFREMER, UMR Ecosyst Lagunaires 5119, F-34095 Montpellier 5, France.
2 : IFREMER, Nouvelle Caledonie, F-98846 Noumea, France.
3 : Skuld Tech, F-34080 Montpellier, France.
Source Molecular Immunology (0161-5890) (Elsevier), 2008-07 , Vol. 45 , N. 12 , P. 3438-3445
DOI 10.1016/j.molimm.2008.04.002
WOS© Times Cited 44
Keyword(s) Real time PCR, Cysteine rich peptide, Crustin, Anti LPS factor, Lysozyme, Penaeidins, Immune response, Vibrio penaeicida, Penaeid, Decapoda, Crustacean
Abstract Understanding of antimicrobial defence mechanisms of penaeid shrimp should help in the design of efficient strategies for the management and disease control in aquaculture. In this study, we have specifically analysed the expression in circulating hemocytes of antimicrobial peptides (AMPs) encoding genes, such as PEN2 and PEN3, ALF, crustin, lysozyme and a putative cysteine-rich peptide. We evidenced a relationship between the level of expression of some AMPs and the successful response of the shrimp, Litopenaeus stylirostris, to circumvent a pathogenic Vibrio penaeicida infection. Additionally, significant differences in some AMP transcript amounts are evidenced between control, non-selected shrimp line and the third generation breeding of shrimp selected for their survival to natural V. penaeicida infections. On the basis of these results, it will now be of great interest to determine if these AMPs are directly involved in the resistance of shrimp to infection or if they only reflect other acquired defence mechanisms which can confer a resistance. (C) 2008 Elsevier Ltd. All rights reserved.
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de Lorgeril Julien, Gueguen Yannick, Goarant Cyrille, Goyard Emmanuel, Mugnier Chantal, Fievet Julie, Piquemal D, Bachere Evelyne (2008). A relationship between antimicrobial peptide gene expression and capacity of a selected shrimp line to survive a Vibrio infection. Molecular Immunology, 45(12), 3438-3445. Publisher's official version : https://doi.org/10.1016/j.molimm.2008.04.002 , Open Access version : https://archimer.ifremer.fr/doc/00000/4524/