FN Archimer Export Format
PT J
TI Effect of Low Molecular Weight Fucoidan and Low Molecular Weight Heparin in a Rabbit Model of Arterial Thrombosis
BT 
AF DURAND, E
   HELLEY, D
   ZEN, A
   DUJOLS, C
   BRUNEVAL, P
   COLLIEC-JOUAULT, Sylvia
   FISCHER, Aurelie
   LAFONT, A
AS 1:1,2,3;2:2,4;3:2,3;4:4;5:2,5;6:6;7:2,4;8:2,3;
FF 1:;2:;3:;4:;5:;6:PDG-DOP-DCB-BM-BMM;7:;8:;
C1 Hop Europeen Georges Pompidou, Serv Cardiol, AP HP, FR-75908 Paris 15, France.
   Univ Paris 05, Fac Med, Paris, France.
   INSERM, U849, Paris, France.
   INSERM, U765, Paris, France.
   INSERM, U430, Paris, France.
   IFREMER, Lab Biotechnol & Mol Marines, Nantes, France.
C2 HOP EUROPEEN GEORGES POMPIDOU, FRANCE
   UNIV PARIS 05, FRANCE
   INSERM, FRANCE
   INSERM, FRANCE
   INSERM, FRANCE
   IFREMER, FRANCE
SI NANTES
SE PDG-DOP-DCB-BM-BMM
IN WOS Ifremer jusqu'en 2018
   copubli-france
   copubli-univ-france
IF 2.792
TC 30
UR https://archimer.ifremer.fr/doc/2008/publication-4744.pdf
LA English
DT Article
DE ;Tissue factor;Tissue factor pathway inhibitor;Heparin;Fucoidan;Thrombosis
AB Background: Therapeutic use of unfractionated heparin and low molecular weight heparins (LMWHs) is limited by hemorrhagic adverse effects. We compared the antithrombotic effect of LMW fucoidan (LMWF) and LMWH in an experimental model. Methods: Thrombosis was induced in femoral arteries of male New Zealand White rabbits by in situ induction of endothelial apoptosis with staurosporine (10(-5) M for 30 min). Starting the day before apoptosis induction, the animals received subcutaneous LMWF (15 mg/kg), LMWH (enoxaparin 2.5 mg/kg) or saline solution (control group) twice a day for 4 days. Results: The degrees of apoptosis and endothelial denudation were similar in the 3 groups. The thrombotic score was significantly lower in the LMWF group than in the LMWH and control groups (p = 0.01). Tissue factor expression was significantly lower in the LMWF group than in the control and LMWH groups (p = 0.01). The plasma concentration of tissue factor pathway inhibitor was significantly increased after LMWF injection (137 +/- 28 vs. 102 +/- 17; p = 0.01), whereas no change was observed after LMWH treatment. LMWF did not prolong the bleeding time or decrease platelet aggregation. Conclusions: LMWF appeared to be more effective than LMWH for preventing arterial thrombosis in this experimental model. LMWF also had a lower hemorrhagic risk than LMWH. Copyright (C) 2008 S. Karger AG, Basel.
PY 2008
PD MAY
SO Journal of Vascular Research
SN 1018-1172
PU Karger
VL 45
IS 6
UT 000260238700008
BP 529
EP 537
DI 10.1159/000129687
ID 4744
ER

EF