Investigation of the matrix effects on a HPLC-ESI-MS/MS method and application for monitoring triazine, phenylurea and chloroacetanilide concentrations in fresh and estuarine waters

Type Article
Date 2009
Language English
Author(s) Mazzella N.1, Delmas F.1, Delest B.1, Mechin B.1, Madigou C.1, Allenou Jean-Pierre2, 3, Gabellec Raoul2, 3, Caquet Th.4
Affiliation(s) 1 : UR REBX, Cemagref, F-33612 Cestas, France.
2 : Inst Francais Rech Exploitat Mer, Lab Cotier Morbihan Pays Loire, Nantes, France.
3 : Inst Francais Rech Exploitat Mer, Lab Cotier Morbihan Pays Loire, La Trinite Sur Mer, France.
4 : INRA, Equipe Ecotoxicol & Qualite Milieux Aquat, F-35042 Rennes, France.
Source Journal of Environmental Monitoring (1464-0325) (Royal Society of Chemistry), 2009 , Vol. 11 , N. 1 , P. 108-115
DOI 10.1039/b805160g
WOS© Times Cited 29
Keyword(s) river estuarine interface, natural water quality, herbicides, matrix effects, multiresidue method, HPLC ESI MS/MS
Abstract In this work, the effects of matrix interferences on the analytical performance of a new multiresidue method based on off-line solid phase extraction followed by reversed-phase liquid chromatographic separation and electrospray triple quadrupole mass spectrometric detection were investigated. This technique allows the simultaneous determination of 30 triazines, phenylureas and chloroacetanilides, extracted from freshwaters, in 40 minutes. Quantifications were performed with the use of appropriate internal standards (i.e. atrazine D5, diuron D6 and metolachlor D6). The limits of quantification were from 1 to 32 ng L-1 for the triazines, from 5 to 59 ng L-1 for the phenylureas and from 13 to 54 ng L-1 for the chloroacetanilides. The matrix effects were studied by spiking various waters (i.e. tap, river, pond and sea waters) with the chemicals of interest. The results showed that the samples with the highest conductivity (i.e. seawater) and the most abundant dissolved organic matter content (i.e. pond water) exhibited important matrix effects with signal suppressions and high imprecision, respectively. These matrix effects were strongly minimized by performing appropriate internal standardizations. Afterward, this analytical method was applied for analyzing environmental samples from either river or estuarine waters and for monitoring herbicide input in a freshwater-seawater interface.
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Mazzella N., Delmas F., Delest B., Mechin B., Madigou C., Allenou Jean-Pierre, Gabellec Raoul, Caquet Th. (2009). Investigation of the matrix effects on a HPLC-ESI-MS/MS method and application for monitoring triazine, phenylurea and chloroacetanilide concentrations in fresh and estuarine waters. Journal of Environmental Monitoring, 11(1), 108-115. Publisher's official version : https://doi.org/10.1039/b805160g , Open Access version : https://archimer.ifremer.fr/doc/00000/6092/