Floridoside extracted from the red alga Mastocarpus stellatus is a potent activator of the classical complement pathway
|Author(s)||Courtois Anthony1, 2, Simon-Colin Christelle2, Boisset Claire2, Berthou Christian1, Deslandes Eric3, Guezennec Jean2, Bordron Anne1|
|Affiliation(s)||1 : Brest Univ Hosp, Cellular Therapy & Immunobiol Canc Lab, EA2216, Brest, France.
2 : IFREMER, Ctr Brest, Biotechnol & Marine Mol Lab, Brest, France.
3 : Univ Western Brittany, European Inst Marine Studies, LEBHAM, Brest, France.
|Source||Marine drugs (1660-3397) (Molecular Diversity Preservation International), 2008-09 , Vol. 6 , N. 3 , P. 407-417|
|WOS© Times Cited||13|
|Keyword(s)||Complement system, Immunomodulation, Marine algae, Alpha galactosyl glycerol|
|Abstract||Many biological properties of algae have been found to have useful applications in human health, particularly in the fields of oncology and immunology. Floridoside, extracted from the red alga Mastocarpus stellatus, has a structure similar to the xenoantigen Gal alpha 1-3 Gal. This xenoantigen has been described to induce a high immune response in human xenografts and is mediated by natural anti-gal antibodies that activate the classical complement pathway. Based on this property, we analyzed the potential activities of floridoside on the immune system. We demonstrated that floridoside activates a complement cascade via the classical complement pathway, through the recruitment and activation of natural IgM. This algal molecule could represent an important step in the development of a potent new anticomplementary agent for use in therapeutic complement depletion.|