FN Archimer Export Format
PT J
TI Floridoside extracted from the red alga Mastocarpus stellatus is a potent activator of the classical complement pathway
BT 
AF COURTOIS, Anthony
   SIMON-COLIN, Christelle
   BOISSET, Claire
   BERTHOU, Christian
   DESLANDES, Eric
   GUEZENNEC, Jean
   BORDRON, Anne
AS 1:1,2;2:2;3:2;4:1;5:3;6:2;7:1;
FF 1:;2:PDG-DOP-DCB-BM-BMM;3:PDG-DOP-DCB-BM-BMM;4:;5:;6:PDG-DPCP;7:;
C1 Brest Univ Hosp, Cellular Therapy & Immunobiol Canc Lab, EA2216, Brest, France.
   IFREMER, Ctr Brest, Biotechnol & Marine Mol Lab, Brest, France.
   Univ Western Brittany, European Inst Marine Studies, LEBHAM, Brest, France.
C2 UBO, FRANCE
   IFREMER, FRANCE
   UBO, FRANCE
SI BREST
SE PDG-DOP-DCB-BM-BMM
   PDG-DPCP
IN WOS Ifremer jusqu'en 2018
   copubli-france
   copubli-univ-france
IF 1.2
TC 19
UR https://archimer.ifremer.fr/doc/2008/publication-6248.pdf
LA English
DT Article
DE ;Complement system;Immunomodulation;Marine algae;Alpha galactosyl glycerol
AB Many biological properties of algae have been found to have useful applications in human health, particularly in the fields of oncology and immunology. Floridoside, extracted from the red alga Mastocarpus stellatus, has a structure similar to the xenoantigen Gal alpha 1-3 Gal. This xenoantigen has been described to induce a high immune response in human xenografts and is mediated by natural anti-gal antibodies that activate the classical complement pathway. Based on this property, we analyzed the potential activities of floridoside on the immune system. We demonstrated that floridoside activates a complement cascade via the classical complement pathway, through the recruitment and activation of natural IgM. This algal molecule could represent an important step in the development of a potent new anticomplementary agent for use in therapeutic complement depletion.
PY 2008
PD SEP
SO Marine drugs
SN 1660-3397
PU Molecular Diversity Preservation International
VL 6
IS 3
UT 000259656900001
BP 407
EP 417
DI 10.3390/md20080019
ID 6248
ER

EF