FN Archimer Export Format PT J TI Influence of dietary phospholipids on early ontogenesis of fish BT AF CAHU, Chantal GISBERT, Enric VILLENEUVE, Laure A. N. MORAIS, Sofia HAMZA, Neila WOLD, Per-Avid ZAMBONINO-INFANTE, Jose-Luis AS 1:1;2:2;3:1;4:3;5:4;6:5;7:1; FF 1:PDG-DOP-DCB-PFOM;2:;3:;4:;5:;6:;7:PDG-DOP-DCB-PFOM-ARN; C1 IFREMER, Nutr Aquaculture & Genom Res Unit, F-29280 Plouzane, France. IRTA St Carles Rapita, Unitat Cultius Expt, Tarragona, Spain. Univ Algarve, CCMAR, Ctr Marine Sci, Faro, Portugal. INSTM 28, Salammbo, Tunisia. Norwegian Univ Sci & Technol, Dept Biol, N-7034 Trondheim, Norway. C2 IFREMER, FRANCE IRTA, SPAIN UNIV ALGARVE, PORTUGAL INSTM, TUNISIA UNIV SCI & TECHNOL NORWEGIAN, NORWAY SI BREST SE PDG-DOP-DCB-PFOM PDG-DOP-DCB-PFOM-ARN IN WOS Ifremer jusqu'en 2018 copubli-europe copubli-int-hors-europe copubli-sud IF 1.099 TC 78 UR https://archimer.ifremer.fr/doc/2009/publication-6460.pdf LA English DT Article DE ;Gene regulation;Skeletal development;Digestive functions;Fish larvae;Phospholipid AB The aim of this paper is to provide explanations of how dietary phospholipid (PL) globally improves fish larval development, including growth and survival, digestive functions and skeletal development, and to propose optimal PL levels and sources in fish larval diets. Dietary incorporation of 8-12% PL related to dry matter (d.m.) promotes growth and enhanced survival in various species. Marine source PL, incorporating highly unsaturated fatty acids, was most efficient than soybean lecithin. This beneficial effect was explained by an enhancement in digestive functions, assessed by digestive enzyme activities and histomorphology. Nevertheless, 1.5-2.5% highly unsaturated fatty acids related to diet d.m. supplied by PL improved growth, survival and skeletal development, while 5% induced different skeletal deformities. The high incidence of deformities was associated with the down-regulation of genes involved in development, such as RXR alpha, RAR alpha, RAR beta and BMP-4, observed in the early stages in larvae fed a high highly unsaturated fatty acids level. PY 2009 PD JUL SO Aquaculture Research SN 1355-557X PU Wiley / Blackwell VL 40 IS 9 UT 000266636500001 BP 989 EP 999 DI 10.1111/j.1365-2109.2009.02190.x ID 6460 ER EF