FN Archimer Export Format PT J TI Investigation of the antifouling constituents from the brown alga Sargassum muticum (Yendo) Fensholt BT AF BAZES, Alexandra SILKINA, Alla DOUZENEL, Philippe FAY, Fabienne KERVAREC, Nelly MORIN, Danièle BERGE, Jean-Pascal BOURGOUGNON, Nathalie AS 1:1;2:1;3:2;4:1;5:3;6:1;7:4;8:1; FF 1:;2:;3:;4:;5:;6:;7:PDG-DOP-DCN-STAM;8:; C1 Univ Bretagne Sud, Univ Europeenne Bretagne, Ctr Rech St Maude, Lab Biotechnol & Chim Marines, F-56321 Lorient, France. Univ Bretagne Sud, Univ Europeenne Bretagne, Dept Sci Vie & Mat, UFR Sci & Sci Ingn,CER Yves Coppens, F-56017 Vannes, France. Univ Bretagne Occidentale, Univ Europeenne Bretagne, Lab Resonance Magnet, F-29238 Brest, France. IFREMER, Dept Sci & Tech Alimentaires Marines, F-44311 Nantes 03, France. C2 UBS, FRANCE UBS, FRANCE UBO, FRANCE IFREMER, FRANCE SI NANTES SE PDG-DOP-DCN-STAM IN WOS Ifremer jusqu'en 2018 copubli-france copubli-univ-france IF 1.018 TC 82 UR https://archimer.ifremer.fr/doc/2009/publication-6601.pdf LA English DT Article DE ;Sargassum muticum;Palmitic acid;Dioctyl phthalate;Dichloromethane extract;Brown algae;Antifouling AB One of the most promising alternatives to toxic heavy metal-based paints is offered by the development of antifouling coatings in which the active ingredients are compounds naturally occurring in marine organisms and operating as natural antisettlement agents. Sessile marine macroalgae are remarkably free from settlement by fouling organisms. They produce a wide variety of chemically active metabolites in their surroundings, potentially as an aid to protect themselves against other settling organisms. In this study, a dichloromethane extract from the brown seaweed Sargassum muticum was tested in situ and, after 2 months of immersion, showed less fouling organisms on paints in which the extract was included, compared to paints containing only copper after 2 months of immersion. No barnacles or mussels have been observed on the test rack. Identification by NMR and GC/MS of the effective compound revealed the abundance of palmitic acid, a commonly found fatty acid. Pure palmitic acid showed antibacterial activity at 44 A mu g mL(-1), and also inhibited the growth of the diatom Cylindrotheca closterium at low concentration (EC50 = 45.5 A mu g mL(-1)), and the germination of Ulva lactuca spores at 3 A mu g mL(-1). No cytotoxicity was highlighted, which is promising in the aim of the development of an environmentally friendly antifouling paint. PY 2009 PD AUG SO Journal of Applied Phycology SN 0921-8971 PU Springer VL 21 IS 4 UT 000267682100003 BP 395 EP 403 DI 10.1007/s10811-008-9382-9 ID 6601 ER EF