FN Archimer Export Format
PT J
TI Detection of griseofulvin in a marine strain of Penicillium waksmanii by ion trap mass spectrometry
BT 
AF PETIT, Karina
   MONDEGUER, Florence
   ROQUEBERT, M
   BIARD, J
   POUCHUS, Y
AS 1:;2:;3:;4:;5:;
FF 1:;2:PDG-DEL-MP-PN;3:;4:;5:;
C1 Univ Nantes, Fac Pharm, ISOMer, SMAB, F-44035 Nantes 01, France.
   IFREMER, DEL, PN, F-44311 Nantes, France.
   Museum Natl Hist Nat, Lab Cryptogamie, F-75005 Paris, France.
C2 UNIV NANTES, FRANCE
   IFREMER, FRANCE
   MNHN, FRANCE
SI NANTES
SE PDG-DEL-MP-PN
IN WOS Ifremer jusqu'en 2018
   copubli-france
   copubli-univ-france
IF 2.146
TC 23
UR https://archimer.ifremer.fr/doc/2004/publication-673.pdf
LA English
DT Article
DE ;Mass spectrometry ESI IT/MS;Griseofulvin;Antifungal;Marine fungi;Penicillium waksmanii
AB A marine strain of Penicillium waksmanii Zaleski was isolated from a sample of seawater from shellfish-farming area in the Loire estuary (France). The in vitro marine culture showed an important antifungal activity. Bioassay-guided fractionation was used to purify the crude extract. Dereplication by electrospray-ion trap/mass spectrometry (ESI-IT/MS) afforded the identification of the antifungal compound, after a semi-purification consisting of two stages. A comparison of the ionic composition between the active and the non-active fractions allowed the detection of a monocharged ion at m/z 353 containing a chlorine atom, which could be attributed to the antifungal griseofulvin [C17H17ClO6+H](+). Multi-stage fragmentation (MSn) confirmed the identity of the m/z 353 ion of the antifungal fraction as griseofulvin. It is the first description of griseofulvin production by a strain of P. waksmanii and the first chemical study of a strain of this species isolated from marine temperate cold water. 
PY 2004
PD JUN
SO Journal of Microbiological Methods
SN 0167-7012
PU Elsevier
VL 58
IS 1
UT 000222151900007
BP 59
EP 65
DI 10.1016/j.mimet.2004.03.004
ID 673
ER

EF