FN Archimer Export Format PT J TI Effects of rapeseed meal-glucosinolates on thyroid metabolism and feed utilization in rainbow trout BT AF BUREL, Christine BOUJARD, Thierry KAUSHIK, Sadasivam BOEUF, Gilles MOL, K VAN DER GEYTEN, S DARRAS, V KUHN, E PRADET BALADE, B QUERAT, B QUINSAC, A KROUTI, M RIBAILLIER, D AS 1:;2:;3:;4:;5:;6:;7:;8:;9:;10:;11:;12:;13:; FF 1:;2:;3:;4:;5:;6:;7:;8:;9:;10:;11:;12:;13:; C1 INRA, Stn Hydrobiol, Unite Mixte INRA IFREMER Nutr Poissons, F-64310 St Pee Sur Nivelle, France. IFREMER, Stn Brest, Physiol Poissons Lab, F-29280 Plouzane, France. Catholic Univ Louvain, Lab Comparat Endocrinol, B-3000 Louvain, Belgium. CSIC, Ctr Nacl Biotecnol, E-28049 Madrid, Spain. Museum Natl Hist Nat, Lab Physiol Gen & Comparee, F-75231 Paris, France. Lab Anal CETIOM, F-45160 Ardon, France. C2 INRA, FRANCE IFREMER, FRANCE UCL, BELGIUM CSIC, SPAIN MNHN, FRANCE LAB ANAL CETIOM, FRANCE SI BREST ST PEE SUR NIVELLE SE PDG-DRV-RA-NP PDG-DRV-RA-ARN IN WOS Ifremer jusqu'en 2018 copubli-france copubli-p187 copubli-europe IF 1.909 TC 64 UR https://archimer.ifremer.fr/doc/2001/publication-677.pdf LA English DT Article DE ;Rainbow trout;Iodine;TSH;Deiodinase activity;Thyroid function;Growth;Glucosinolates;Rapeseed AB Two rapeseed meals (RM1 and RM2), containing glucosinolates at a concentration of 26 and 40 mumol/g, respectively, were incorporated at increasing levels (10, 20, and 30% for RM1 and 30 and 50% for RM2) in diets of juvenile rainbow trout. Disturbances in the thyroid axis appeared after 14 days of feeding (with a dietary incorporation level of 10%). The dietary supplementation with T-3 or iodine induced an increase in plasma T-3 levels, compared to that in fish fed the RM diets, and reduced the deleterious effect of RM on growth. When trout were reared in seawater, there was also a slight increase in thyroid hormone levels. TSH treatment had no effect on the thyroid hormone plasma levels. The incorporation of 30% of RM1, which induced a lower dietary content of toxic compounds than RM2, led to a rapid decrease of plasma T-4 and T-3 levels, but growth was affected only after 6 months of feeding. During these studies, the deiodinase activities responded in a complex manner to restore plasma and tissue levels of T-3. PY 2001 PD DEC SO General and Comparative Endocrinology SN 0016-6480 PU Elsevier VL 124 IS 3 UT 000173227000011 BP 343 EP 358 DI 10.1006/gcen.2001.7723 ID 677 ER EF