Chalcogenide Glass Optical Waveguides for Infrared Biosensing

Type Article
Date 2009-09
Language English
Author(s) Anne Marie-Laure1, Keirsse Julie1, Nazabal Virginie1, Hyodo Koji2, Inoue Satoru3, Boussard-Pledel Catherine1, Lhermite Herve4, Charrier Joel5, Yanakata Kiyoyuki6, Loreal Olivier7, Le Person Jenny8, Colas FlorentORCID8, Compere ChantalORCID8, Bureau Bruno1
Affiliation(s) 1 : Univ Rennes 1, UMR 6226, F-35042 Rennes, France.
2 : AIST, Natl Inst Adv Ind Sci & Technol, Inst Human Sci & Biomed Engn, Biomed Sensing & Imaging Grp, Tsukuba, Ibaraki, Japan.
3 : Natl Inst Mat Sci, Tsukuba, Ibaraki 3050041, Japan.
4 : Univ Rennes 1, Inst Elect & Telecommun Rennes Microelect, F-35042 Rennes, France.
5 : Univ Rennes 1, ENSSAT, UMR 6082, FOTON CCLO, F-22305 Lannion, France.
6 : Univ Tsukuba, Inst Clin Med, Dept Neurosurg, Tsukuba, Ibaraki 305, Japan.
7 : Univ Rennes 1, INSERM, IFR 140, U522, F-35042 Rennes, France.
8 : IFREMER, ERT, Serv Interfaces & Capteurs, F-29280 Plouzane, France.
Source Sensors (1424-8220) (Molecular Diversity Preservation International-MDPI), 2009-09 , Vol. 9 , N. 9 , P. 7398-7411
DOI 10.3390/s90907398
WOS© Times Cited 83
Keyword(s) Planar waveguide, Fibre, Optical sensor, Chalcogenide
Abstract Due to the remarkable properties of chalcogenide (Chg) glasses, Chg optical waveguides should play a significant role in the development of optical biosensors. This paper describes the fabrication and properties of chalcogenide fibres and planar waveguides. Using optical fibre transparent in the mid-infrared spectral range we have developed a biosensor that can collect information on whole metabolism alterations, rapidly and in situ. Thanks to this sensor it is possible to collect infrared spectra by remote spectroscopy, by simple contact with the sample. In this way, we tried to determine spectral modifications due, on the one hand, to cerebral metabolism alterations caused by a transient focal ischemia in the rat brain and, in the other hand, starvation in the mouse liver. We also applied a microdialysis method, a well known technique for in vivo brain metabolism studies, as reference. In the field of integrated microsensors, reactive ion etching was used to pattern rib waveguides between 2 and 300 mu m wide. This technique was used to fabricate Y optical junctions for optical interconnections on chalcogenide amorphous films, which can potentially increase the sensitivity and stability of an optical micro-sensor. The first tests were also carried out to functionalise the Chg planar waveguides with the aim of using them as (bio) sensors.
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Anne Marie-Laure, Keirsse Julie, Nazabal Virginie, Hyodo Koji, Inoue Satoru, Boussard-Pledel Catherine, Lhermite Herve, Charrier Joel, Yanakata Kiyoyuki, Loreal Olivier, Le Person Jenny, Colas Florent, Compere Chantal, Bureau Bruno (2009). Chalcogenide Glass Optical Waveguides for Infrared Biosensing. Sensors, 9(9), 7398-7411. Publisher's official version : https://doi.org/10.3390/s90907398 , Open Access version : https://archimer.ifremer.fr/doc/00000/6851/