TY - JOUR T1 - Chalcogenide Glass Optical Waveguides for Infrared Biosensing A1 - Anne,Marie-Laure A1 - Keirsse,Julie A1 - Nazabal,Virginie A1 - Hyodo,Koji A1 - Inoue,Satoru A1 - Boussard-Pledel,Catherine A1 - Lhermite,Herve A1 - Charrier,Joel A1 - Yanakata,Kiyoyuki A1 - Loreal,Olivier A1 - Le Person,Jenny A1 - Colas,Florent A1 - Compere,Chantal A1 - Bureau,Bruno AD - Univ Rennes 1, UMR 6226, F-35042 Rennes, France. AD - AIST, Natl Inst Adv Ind Sci & Technol, Inst Human Sci & Biomed Engn, Biomed Sensing & Imaging Grp, Tsukuba, Ibaraki, Japan. AD - Natl Inst Mat Sci, Tsukuba, Ibaraki 3050041, Japan. AD - Univ Rennes 1, Inst Elect & Telecommun Rennes Microelect, F-35042 Rennes, France. AD - Univ Rennes 1, ENSSAT, UMR 6082, FOTON CCLO, F-22305 Lannion, France. AD - Univ Tsukuba, Inst Clin Med, Dept Neurosurg, Tsukuba, Ibaraki 305, Japan. AD - Univ Rennes 1, INSERM, IFR 140, U522, F-35042 Rennes, France. AD - IFREMER, ERT, Serv Interfaces & Capteurs, F-29280 Plouzane, France. UR - https://archimer.ifremer.fr/doc/00000/6851/ DO - 10.3390/s90907398 KW - Planar waveguide KW - Fibre KW - Optical sensor KW - Chalcogenide N2 - Due to the remarkable properties of chalcogenide (Chg) glasses, Chg optical waveguides should play a significant role in the development of optical biosensors. This paper describes the fabrication and properties of chalcogenide fibres and planar waveguides. Using optical fibre transparent in the mid-infrared spectral range we have developed a biosensor that can collect information on whole metabolism alterations, rapidly and in situ. Thanks to this sensor it is possible to collect infrared spectra by remote spectroscopy, by simple contact with the sample. In this way, we tried to determine spectral modifications due, on the one hand, to cerebral metabolism alterations caused by a transient focal ischemia in the rat brain and, in the other hand, starvation in the mouse liver. We also applied a microdialysis method, a well known technique for in vivo brain metabolism studies, as reference. In the field of integrated microsensors, reactive ion etching was used to pattern rib waveguides between 2 and 300 mu m wide. This technique was used to fabricate Y optical junctions for optical interconnections on chalcogenide amorphous films, which can potentially increase the sensitivity and stability of an optical micro-sensor. The first tests were also carried out to functionalise the Chg planar waveguides with the aim of using them as (bio) sensors. Y1 - 2009/09 PB - Molecular Diversity Preservation International-MDPI JF - Sensors SN - 1424-8220 VL - 9 IS - 9 SP - 7398 EP - 7411 ID - 6851 ER -