Lack of significant long-term effect of dietary carbohydrates on hepatic glucose-6-phosphatase expression in rainbow trout (Oncorhynchus mykiss)

Type Article
Date 2000
Language English
Author(s) Panserat Stéphane, Medale Francoise, Breque Jeanine, Plagnes Juan E, Kaushik Sadasivam
Affiliation(s) IFREMER, INRA, Lab Fish Nutr, F-64310 St Pee Sur Nivelle, France.
Source The Journal of Nutritional Biochemistry (0955-2863) (Elsevier), 2000 , Vol. 11 , N. 1 , P. 22-29
DOI 10.1016/S0955-2863(99)00067-4
WOS© Times Cited 100
Keyword(s) Dietary carbohydrates, Rainbow trout, Fish nutrition, Glucose 6 phosphatase expression
Abstract Hepatic glucose-6-phosphatase (G6Pase) plays an important role in glucose metabolism because it catalyzes the release of glucose to the circulatory system in the processes of glycogenolysis and gluconeogenesis. The present study was initiated to analyze the regulation of hepatic G6Pase expression by dietary carbohydrates in rainbow trout. The first step in our study was the identification of a partial G6Pase cDNA in rainbow trout that was highly homologous to that of mammals. Hepatic G6Pase activities and mRNA levels were measured in trout fed one of the experimental diets, with or without carbohydrates. We found no significant effect of intake of dietary carbohydrates on G6Pase Expression (mRNA and activity) 6 hours and 24 hours after feeding. These results suggest that there is no control of G6Pase synthesis by dietary carbohydrates in rainbow trout and that the lack of regulation of gluconeogenesis by dietary carbohydrates could at least partially explain the postprandial hyperglycemia and the low dietary glucose utilization observed in this species. (J. Nutr. Biochem. 11:22-29, 2000)
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Panserat Stéphane, Medale Francoise, Breque Jeanine, Plagnes Juan E, Kaushik Sadasivam (2000). Lack of significant long-term effect of dietary carbohydrates on hepatic glucose-6-phosphatase expression in rainbow trout (Oncorhynchus mykiss). The Journal of Nutritional Biochemistry, 11(1), 22-29. Publisher's official version : https://doi.org/10.1016/S0955-2863(99)00067-4 , Open Access version : https://archimer.ifremer.fr/doc/00000/696/