FN Archimer Export Format
PT J
TI Putative antiviral activity in hemolymph from adult Pacific oysters, Crassostrea gigas
BT 
AF OLICARD, Cecile
   RENAULT, Tristan
   TORHY, Corinne
   BENMANSOUR, Abdenour
   BOURGOUGNON, Nathalie
AS 1:1,2,3;2:2;3:4;4:4;5:1;
FF 1:;2:PDG-DOP-DCN-AGSAE-LGP;3:;4:;5:;
C1 Univ Bretagne Sud, Lab Biotechnol & Chim Marines, EA 2594, Ctr Rech Yves Coppens, F-56017 Vannes, France.
   IFREMER, Lab Genet & Pathol, F-17390 La Tremblade, France.
   Univ La Rochelle, Lab Biol & Environm Marins, F-17042 La Rochelle, France.
   INRA, Unite Virol & Immunol Mol, F-78352 Jouy En Josas, France.
C2 UBS, FRANCE
   IFREMER, FRANCE
   UNIV LA ROCHELLE, FRANCE
   INRA, FRANCE
SI LA TREMBLADE
SE PDG-DOP-DCN-AGSAE-LGP
IN WOS Ifremer jusqu'en 2018
   copubli-france
   copubli-p187
   copubli-univ-france
IF 3.406
TC 42
UR https://archimer.ifremer.fr/doc/2005/publication-774.pdf
LA English
DT Article
DE ;Hemolymph;VHSV;IPNV;HSV;Antiviral defense;Crassosirea gigas;Oyster
AB Innate, non-specific resistance mechanisms are important to pathogens, particularly for delaying virus replication at the onset of infection, Innate immunity constitutes the first line of defense in vertebrates and is the only one in invertebrates. Little is known about possible antiviral substances in invertebrates. The present work concerns a Study of antiviral substances in hemolymph from adult Crassostrea gigas oysters. Despite the detection of cytotoxicity in fresh filtered hemolymph for both mammalian (CC50: 750 mu g/ml) and fish cells (CC50: > 2000 mu g/ml for EPC cells and 345 mu g/ml for RTG-2 cells), an antiviral substance was detected. Fresh filtered hemolymph was capable of inhibiting the replication of herpes simplex virus type I in vitro at an EC50 of 425 mu g/ml (total proteins) and the replication of infections pancreatic necrosis virus in EPC and RTG-2 cells at 217 and 156 mu g/ml (total proteins), respectively. 
PY 2005
PD JUL
SO Antiviral Research
SN 0166-3542
PU Elsevier
VL 66
IS 2-3
UT 000229819900008
BP 147
EP 152
DI 10.1016/j.antiviral.2005.03.003
ID 774
ER

EF