FN Archimer Export Format PT J TI A herpes-like virus infects a non-ostreid bivalve species: virus replication in Ruditapes philippinarum larvae BT AF RENAULT, Tristan LIPART, Cecile ARZUL, Isabelle AS 1:;2:;3:; FF 1:PDG-DRV-RA-LGP;2:;3:PDG-DRV-RA-LGP; C1 Inst Francais Rech Exploitat Mer, Lab Genet & Pathol, F-17390 La Tremblade, France. C2 IFREMER, FRANCE SI LA TREMBLADE LA TREMBLADE RONCE SE PDG-DRV-RA-LGP PDG-DRV-RA-GAP IN WOS Ifremer jusqu'en 2018 IF 1.653 TC 62 UR https://archimer.ifremer.fr/doc/2001/publication-816.pdf LA English DT Article DE ;Apoptosis;Virus replication;Mortality;Ruditapes philippinarum;Manila clam;Herpes like virus AB Sporadic high mortalities were reported in June 1997 among hatchery-reared larval Manila clam Ruditapes philippinarum in a French commercial hatchery. Cellular abnormalities were observed in semi-thin sections in affected animals. Transmission electron microscopy revealed the presence of herpes-like virus particles in larvae. This is the first description of a herpes-like virus infection in larval R. philippinarum, a non-ostreid bivalve species. Virus particles were similar to other herpes-like viruses described from different oyster species with respect to ultrastructure and morphogenesis. Electron microscopic examination also demonstrated cells with condensed chromatin and extensive perinuclear fragmentation of chromatin. Like viruses infecting oysters, the herpes-like virus detected in clams may induce apoptosis in infected animals. PY 2001 PD MAY SO Diseases of aquatic organisms SN 0177-5103 PU Inter-Research VL 45 IS 1 UT 000168965300001 BP 1 EP 7 ID 816 ER EF