FN Archimer Export Format PT J TI Multiple biomarkers of pollution effects in caged mussels on the Greek coastline BT AF TSANGARIS, C. KORMAS, K. STROGYLOUDI, E. HATZIANESTIS, I. NEOFITOU, C. ANDRAL, Bruno GALGANI, Francois AS 1:;2:;3:;4:;5:;6:;7:; FF 1:;2:;3:;4:;5:;6:PDG-DOP-LER-LERPAC;7:PDG-DOP-LER-LERPAC; C1 Hellen Ctr Marine Res, Inst Oceanog, Anavyssos 19013, Greece. Univ Thessaly, Fac Agr Sci, Dept Ichthyol & Aquat Environm, N Ionia Volos 38446, Greece. IFREMER, Lab Provence Azur Corse, F-83507 La Seyne Sur Mer, France. IFREMER, Lab Environm Ressources Languedoc Roussillon, F-34203 Sete, France. C2 HELLEN CTR MARINE RES, GREECE UNIV THESSALY, GREECE IFREMER, FRANCE IFREMER, FRANCE SI TOULON CORSE SE PDG-DOP-LER-LERPAC IN WOS Ifremer jusqu'en 2018 copubli-europe IF 2.325 TC 92 UR https://archimer.ifremer.fr/doc/00002/11286/7890.pdf LA English DT Article CR MYTIMED 2007 / 1 MYTIMED 2007 / 2 BO L'Europe DE ;Biomarkers;AchE;CAT;GST;MTS;RNA:DNA ratio;Mytilus galloprovincialis;Mediterranean AB A suite of biomarkers was measured in caged mussels at areas impacted by different anthropogenic activities along the Greek coastline to assess biological effects of environmental pollution. Mussels were caged at coastal sites in the vicinity of major cities, in areas influenced by major industries, agricultural practices and in islands away from known sources of pollution. Biomarkers indicative of neurotoxicity (acetylcholinesterase, AchE), oxidative stress (catalase, CAT), phase 11 biotransformation of xenobiotics (glutathione S-transferase, GST), metal exposure (metallothioneins, MTs) and protein synthesis (RNA:DNA ratio) were measured to assess effects of various types of pollutants. AchE activity proved to be the most responsive biomarker with decreased values at sites influenced by agricultural, urban and industrial activities. Decreased CAT and GST activities and increased MTs levels were recorded at a number of anthropogenic-impacted sites. RNA:DNA ratio showed a biphasic response as both high and low values were found at impacted sites. Principal component analysis clearly distinguished sites receiving pollution inputs from non-polluted sites. The combination of the selected biomarkers used in caged mussels resulted useful in the assessment of the effects of environmental pollution. PY 2010 PD APR SO Comparative Biochemistry And Physiology C-toxicology & Pharmacology SN 1532-0456 PU Elsevier Science Inc VL 151 IS 3 UT 000275627400014 BP 369 EP 378 DI 10.1016/j.cbpc.2009.12.009 ID 11286 ER EF