Comprehensive Analysis of a Norovirus-Associated Gastroenteritis Outbreak, from the Environment to the Consumer

Type Article
Date 2010-03
Language English
Author(s) Le Guyader Soizick1, Krol Joanna1, Ambert-Balay Katia2, Ruvoen-Clouet Nathalie3, 4, Desaubliaux Benedicte5, Parnaudeau Sylvain1, Le Saux Jean-Claude1, Ponge Agnes5, Pothier Pierre2, Atmar Robert L.6, Le Pendu Jacques3
Affiliation(s) 1 : IFREMER, Microbiol Lab, F-44311 Nantes 03, France.
2 : CHU, Reference Lab Enter Viruses, Lab Virol & Microbiol Med & Mol, Dijon, France.
3 : Univ Nantes, INSERM, U892, Nantes, France.
4 : Ecole Natl Vet, Nantes, France.
5 : DDASS, Dept Sante, Nantes, France.
6 : Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA.
Source Journal Of Clinical Microbiology (0095-1137) (American Society Microbiology), 2010-03 , Vol. 48 , N. 3 , P. 915-920
DOI 10.1128/JCM.01664-09
WOS© Times Cited 59
Abstract Noroviruses have been recognized to be the predominant agents of nonbacterial gastroenteritis outbreaks in humans, and their transmission via contaminated shellfish consumption has been demonstrated. Norovirus laboratory experiments, volunteer challenge studies, and community gastroenteritis outbreak investigations have identified human genetic susceptibility factors related to histo-blood group antigen expression. Following a banquet in Brittany, France, in February 2008, gastroenteritis cases were linked to oyster consumption. This study identified an association of the norovirus illnesses with histo-blood group expression, and oyster contamination with norovirus was confirmed by qualitative and quantitative analyses. The secretor phenotype was associated with illness, especially for the non-A subgroup. The study showed that, in addition to accidental climatic events that may lead to oyster contamination, illegal shellfish collection and trading are also risk factors associated with outbreaks.
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Le Guyader Soizick, Krol Joanna, Ambert-Balay Katia, Ruvoen-Clouet Nathalie, Desaubliaux Benedicte, Parnaudeau Sylvain, Le Saux Jean-Claude, Ponge Agnes, Pothier Pierre, Atmar Robert L., Le Pendu Jacques (2010). Comprehensive Analysis of a Norovirus-Associated Gastroenteritis Outbreak, from the Environment to the Consumer. Journal Of Clinical Microbiology, 48(3), 915-920. Publisher's official version : https://doi.org/10.1128/JCM.01664-09 , Open Access version : https://archimer.ifremer.fr/doc/00002/11309/