FN Archimer Export Format
PT J
TI Distribution in Tissue and Seasonal Variation of Norovirus Genogroup I and II Ligands in Oysters
BT 
AF MAALOUF, Haifa
   ZAKHOUR, Maha
   LE PENDU, Jacques
   LE SAUX, Jean-Claude
   ATMAR, Robert L.
   LE GUYADER, Francoise S.
AS 1:1;2:2;3:2;4:1;5:3;6:1;
FF 1:PDG-DOP-DCN-EMP-MIC;2:;3:;4:PDG-DOP-DCN-EMP-MIC;5:;6:;
C1 IFREMER, Microbiol Lab, F-44311 Nantes 03, France.
   Univ Nantes, INSERM, U892, Nantes, France.
   Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA.
C2 IFREMER, FRANCE
   UNIV NANTES, FRANCE
   BAYLOR COLL MED, USA
SI NANTES
   BREST
SE PDG-DOP-DCN-EMP-MIC
IN WOS Ifremer jusqu'en 2018
   copubli-france
   copubli-univ-france
   copubli-int-hors-europe
IF 3.778
TC 101
UR https://archimer.ifremer.fr/doc/00011/12215/9045.pdf
LA English
DT Article
AB Bivalve molluscan shellfish, such as oysters, filter large volumes of water as part of their feeding activities and are able to accumulate and concentrate different types of pathogens, particularly noroviruses, from fecal human pollution. Based on our previous observation of a specific binding of the Norwalk strain (prototype norovirus genogroup I) to the oyster digestive tract through an A-like carbohydrate structure indistinguishable from human blood group A antigen and on the large diversity between strains in terms of carbohydrate-binding specificities, we evaluated the different ligands implicated in attachment to oysters tissues of strains representative of two main genogroups of human norovirus. The GI.1 and GII.4 strains differed in that the latter recognized a sialic acid-containing ligand, present in all tissues, in addition to the A-like ligand of the digestive tract shared with the GI.1 strain. Furthermore, bioaccumulation experiments using wild-type or mutant GI.1 Viruslike particles showed accumulation in hemocytes largely, but not exclusively, based on interaction with the A-like ligand. Moreover, a seasonal effect on the expression of these ligands was detected, most visibly for the GI.1 strain, with a peak in late winter and spring, a period when GI strains are regularly involved in oyster-related outbreaks. These observations may explain some of the distinct epidemiological features of strains from different genogroups.
PY 2010
PD AUG
SO Applied And Environmental Microbiology
SN 0099-2240
PU Amer Soc Microbiology
VL 76
IS 16
UT 000280633400035
BP 5621
EP 5630
DI 10.1128/AEM.00148-10
ID 12215
ER

EF