Bovine Norovirus: Carbohydrate Ligand, Environmental Contamination, and Potential Cross-Species Transmission via Oysters

Type Article
Date 2010-10
Language English
Author(s) Zakhour Maha, Maalouf Haifa2, Di Bartolo Ilaria3, Haugarreau Larissa2, Le Guyader Francoise2, Ruvoen-Clouet Nathalie4, Le Saux Jean-Claude2, Ruggeri Franco Maria3, Pommepuy Monique2, Le Pendu Jacques1
Affiliation(s) 1 : Univ Nantes, Inst Rech Therapeut, INSERM, U892, F-44007 Nantes 1, France.
2 : IFREMER, Microbiol Lab, Nantes, France.
3 : Ist Super Sanita, I-00161 Rome, Italy.
4 : Ecole Natl Vet Agroalimentaire & Alimentat Nantes, Nantes, France.
Source Applied And Environmental Microbiology (0099-2240) (Amer Soc Microbiology), 2010-10 , Vol. 76 , N. 19 , P. 6404-6411
DOI 10.1128/AEM.00671-10
WOS© Times Cited 30
Abstract Noroviruses (NoV) are major agents of acute gastroenteritis in humans and the primary pathogens of shellfish-related outbreaks. Previous studies showed that some human strains bind to oyster tissues through carbohydrate ligands that are similar to their human receptors. Thus, based on presentation of shared norovirus carbohydrate ligands, oysters could selectively concentrate animal strains with increased ability to overcome species barriers. In comparison with human GI and GII strains, bovine GIII NoV strains, although frequently detected in bovine feces and waters of two estuaries of Brittany, were seldom detected in oysters grown in these estuaries. Characterization of the carbohydrate ligand from a new GIII strain indicated recognition of the alpha-galactosidase (alpha-Gal) epitope not expressed by humans, similar to the GIII. 2 Newbury2 strain. This ligand was not detectable on oyster tissues, suggesting that oysters may not be able to accumulate substantial amounts of GIII strains due to the lack of shared carbohydrate ligand and that they should be unable to contribute to select GIII strains with an increased ability to recognize humans.
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Zakhour Maha, Maalouf Haifa, Di Bartolo Ilaria, Haugarreau Larissa, Le Guyader Francoise, Ruvoen-Clouet Nathalie, Le Saux Jean-Claude, Ruggeri Franco Maria, Pommepuy Monique, Le Pendu Jacques (2010). Bovine Norovirus: Carbohydrate Ligand, Environmental Contamination, and Potential Cross-Species Transmission via Oysters. Applied And Environmental Microbiology, 76(19), 6404-6411. Publisher's official version : https://doi.org/10.1128/AEM.00671-10 , Open Access version : https://archimer.ifremer.fr/doc/00014/12534/