FN Archimer Export Format PT J TI Bovine Norovirus: Carbohydrate Ligand, Environmental Contamination, and Potential Cross-Species Transmission via Oysters BT AF ZAKHOUR, Maha MAALOUF, Haifa DI BARTOLO, Ilaria HAUGARREAU, Larissa LE GUYADER, Francoise RUVOEN-CLOUET, Nathalie LE SAUX, Jean-Claude RUGGERI, Franco Maria POMMEPUY, Monique LE PENDU, Jacques AS 1:;2:2;3:3;4:2;5:2;6:4;7:2;8:3;9:2;10:1; FF 1:;2:PDG-DOP-DCN-EMP-MIC;3:;4:PDG-DOP-DCN-EMP-MIC;5:PDG-DOP-DCN-EMP-MIC;6:;7:PDG-DOP-DCN-EMP-MIC;8:;9:PDG-DOP-DCN-EMP-MIC;10:; C1 Univ Nantes, Inst Rech Therapeut, INSERM, U892, F-44007 Nantes 1, France. IFREMER, Microbiol Lab, Nantes, France. Ist Super Sanita, I-00161 Rome, Italy. Ecole Natl Vet Agroalimentaire & Alimentat Nantes, Nantes, France. C2 UNIV NANTES, FRANCE IFREMER, FRANCE IST SUPER SANITA, ITALY ECOLE NATL VET AGROALIMENTAIRE & ALIMENTAT NANTES, FRANCE SI NANTES BREST SE PDG-DOP-DCN-EMP-MIC IN WOS Ifremer jusqu'en 2018 copubli-france copubli-europe copubli-univ-france IF 3.778 TC 33 UR https://archimer.ifremer.fr/doc/00014/12534/9527.pdf LA English DT Article AB Noroviruses (NoV) are major agents of acute gastroenteritis in humans and the primary pathogens of shellfish-related outbreaks. Previous studies showed that some human strains bind to oyster tissues through carbohydrate ligands that are similar to their human receptors. Thus, based on presentation of shared norovirus carbohydrate ligands, oysters could selectively concentrate animal strains with increased ability to overcome species barriers. In comparison with human GI and GII strains, bovine GIII NoV strains, although frequently detected in bovine feces and waters of two estuaries of Brittany, were seldom detected in oysters grown in these estuaries. Characterization of the carbohydrate ligand from a new GIII strain indicated recognition of the alpha-galactosidase (alpha-Gal) epitope not expressed by humans, similar to the GIII. 2 Newbury2 strain. This ligand was not detectable on oyster tissues, suggesting that oysters may not be able to accumulate substantial amounts of GIII strains due to the lack of shared carbohydrate ligand and that they should be unable to contribute to select GIII strains with an increased ability to recognize humans. PY 2010 PD OCT SO Applied And Environmental Microbiology SN 0099-2240 PU Amer Soc Microbiology VL 76 IS 19 UT 000282136700009 BP 6404 EP 6411 DI 10.1128/AEM.00671-10 ID 12534 ER EF