FN Archimer Export Format PT J TI Dietary exposure of juvenile common sole (Solea solea L.) to polybrominated diphenyl ethers (PBDEs): Part 2. Formation, bioaccumulation and elimination of hydroxylated metabolites BT AF MUNSCHY, Catherine MOISAN, Karine TIXIER, Celine PACEPAVICIUS, G. ALAEE, M. AS 1:1;2:1;3:1;4:2;5:2; FF 1:PDG-DOP-DCN-BE-LBCO;2:PDG-DOP-DCN-BE-LBCO;3:PDG-DOP-DCN-BE-LBCO;4:;5:; C1 Inst Francais Rech Exploitat Mer IFREMER, Lab Biogeochem Organ Contaminants, F-44311 Nantes 3, France. Environm Canada, Aquat Ecosyst Protect Res Div, Burlington, ON L7R 4A6, Canada. C2 IFREMER, FRANCE ENVIRONM CANADA, CANADA SI NANTES SE PDG-DOP-DCN-BE-LBCO IN WOS Ifremer jusqu'en 2018 copubli-int-hors-europe IF 3.395 TC 20 UR https://archimer.ifremer.fr/doc/00017/12811/11295.pdf LA English DT Article DE ;Marine flatfish;PBDEs;Bioaccumulation;Biotransformation;Hydroxylated metabolites AB The uptake, elimination and transformation of six PBDE congeners (BDE-28, -47, -99, -100, -153, -209) were studied in juvenile common sole (Solea solea L) exposed to spiked contaminated food over a three-month period, and then depurated over a five-month period. Methoxylated (MeO-) and hydroxylated (OH-) PBDEs were determined in fish plasma exposed to PBDEs and compared to those obtained in control fish. While all MeO- and some OH- congeners identified in fish plasma were found to originate from non-metabolic sources, several OH- congeners, i.e., OH-tetraBDEs and OH-pentaBDEs, were found to originate from fish metabolism. Among these, 4 '-OH-BDE-49 was identified as a BDE-47 metabolite. Congener 4 '-OH-BDE-101, identified here for the first time, may be the result of BDE-99 metabolic transformation. Our results unequivocally showed that PBDEs are metabolised in juvenile sole via the formation of OH- metabolites. However, this was not a major biotransformation route compared to biotransformation through debromination. (C) 2010 Elsevier Ltd. All rights reserved. PY 2010 PD DEC SO Environmental Pollution SN 0269-7491 PU Elsevier Sci Ltd VL 158 IS 12 UT 000283690500010 BP 3527 EP 3533 DI 10.1016/j.envpol.2010.08.021 ID 12811 ER EF