A Biosensor for Detection of DNA Sequences Based on a 50MHz QCM electronic oscillator circuit

Type Article
Date 2009-10
Language English
Author(s) Bustabad E. A.1, Garcia G1, Rodriguez-Pardo L.1, Farina J.1, Perrot H., Gabrielli C., Bucur B., Lazerges M., Rose D., Compere ChantalORCID, Arnau A.
Affiliation(s) 1 : Univ Vigo, Dpto Tecnol Elect, Vigo 36310, Spain.
Meeting 8th IEEE Conference on Sensors, Christchurch, NEW ZEALAND, OCT 25-28, 2009
Source Sensors (1930-0395) (Ieee), 2009-10 , Vol. 1-3 , P. 687 - 690
DOI 10.1109/ICSENS.2009.5398346
WOS© Times Cited 3
Abstract This work deals with the development of a high sensibility DNA biosensor based on a 50MHz Quartz Crystal Microbalance (QCM) Oscillator Electronic Circuit. The designed QCM oscillator sensor is able to detect the presence of complementary DNAs in a solution that match the sequence on a given strand in function of the changes in the output frequency of the oscillator. The design is adapted so that the Barkhausen condition is satisfied even when the quartz is immerged in liquid media. Also a comparative study of the developed 50MHz biosensor in front of a QCM oscillator with smaller frequency is carried out, with object of checking if the sensibility of the oscillator increases, allowing to detect smaller concentrations of the complementary DNA.
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