FN Archimer Export Format
PT J
TI Virulence of an emerging pathogenic lineage of Vibrio nigripulchritudo is dependent on two plasmids
BT 
AF LE ROUX, Frederique
   LABREUCHE, Yannick
   DAVIS, Brigid M.
   IQBAL, Naeem
   MANGENOT, Sophie
   GOARANT, Cyrille
   MAZEL, Didier
   WALDOR, Matthew K.
AS 1:1,2,3;2:4;3:2,3;4:5,6;5:7,8;6:9;7:5,6;8:2,3,10;
FF 1:PDG-RBE-PFOM;2:PDG-RBE-LEADNC-LAC;3:;4:;5:;6:;7:;8:;
C1 IFREMER, Lab Genet & Pathol, F-3790 La Tremblade, France.
   Brigham & Womens Hosp, Channing Lab, Boston, MA 02115 USA.
   Harvard Univ, Sch Med, Boston, MA 02115 USA.
   IFREMER, Dept Lagons Ecosyst & Aquaculture Durable Nouvell, Noumea 98846, New Caledonia.
   Inst Pasteur, Unite Plasticite Genome Bacterien, Dept Genomes & Genet, F-75015 Paris, France.
   CNRS, URA2171, F-75015 Paris, France.
   CEA, Inst Genom, Evry, France.
   CNRS, UMR8030, Lab Genom Comparat, Evry, France.
   Inst Pasteur, Noumea, New Caledonia.
   HHMI, Boston, MA 02115 USA.
C2 IFREMER, FRANCE
   BRIGHAM & WOMENS HOSP, USA
   HARVARD UNIV, USA
   IFREMER, FRANCE
   INST PASTEUR, FRANCE
   CNRS, FRANCE
   CEA, FRANCE
   CNRS, FRANCE
   INST PASTEUR, FRANCE
   HHMI, USA
SI BREST
   SAINT VINCENT
SE PDG-RBE-PFOM
   PDG-RBE-LEADNC-LAC
IN WOS Ifremer jusqu'en 2018
   copubli-france
   copubli-int-hors-europe
IF 5.843
TC 28
UR https://archimer.ifremer.fr/doc/00031/14196/11469.pdf
LA English
DT Article
AB Vibrioses are the predominant bacterial infections in marine shrimp farms. Vibrio nigripulchritudo is an emerging pathogen of the cultured shrimp Litopenaeus stylirostris in New Caledonia and other regions in the Indo-Pacific. The molecular determinants of V. nigripulchritudo pathogenicity are unknown; however, molecular epidemiological studies have revealed that recent pathogenic V. nigripulchritudo isolates from New Caledonia all cluster into a monophyletic clade and contain a small plasmid, pB1067. Here, we report that a large plasmid, pA1066 (247 kb), can also serve as a marker for virulent V. nigripulchritudo, and that an ancestral version of this plasmid was likely acquired prior to other virulence-linked markers. Additionally, we demonstrate that pA1066 is critical for the full virulence of V. nigripulchritudo in several newly developed experimental models of infection. Plasmid pB1067 also contributes to virulence; only strains containing both plasmids induced the highest level of shrimp mortality. Thus, it appears that these plasmids, which are absent from non-pathogenic isolates, may be driving forces, as well as markers, for the emergence of a pathogenic lineage of V. nigripulchritudo.
PY 2011
PD FEB
SO Environmental Microbiology
SN 1462-2912
PU Wiley-blackwell Publishing, Inc
VL 13
IS 2
UT 000286835900003
BP 296
EP 306
DI 10.1111/j.1462-2920.2010.02329.x
ID 14196
ER

EF