FN Archimer Export Format
PT J
TI A mussel tissue certified reference material for multiple phycotoxins. Part 1: design and preparation
BT 
AF MCCARRON, Pearse
   EMTEBORG, Hakan
   NULTY, Ciara
   RUNDBERGET, Thomas
   LOADER, Jared I.
   TEIPEL, Katharina
   MILES, Christopher O.
   QUILLIAM, Michael A.
   HESS, Philipp
AS 1:1,2;2:3;3:2;4:4;5:5;6:3;7:4,5;8:1;9:2;
FF 1:;2:;3:;4:;5:;6:;7:;8:;9:PDG-ODE-LITTORAL-PHYC;
C1 Natl Res Council Canada, Inst Marine Biosci, Halifax, NS B3H 3Z1, Canada.
   Inst Marine, Galway, Ireland.
   Commiss European Communities, Joint Res Ctr, Inst Reference Mat & Measurements, B-2440 Geel, Belgium.
   Natl Vet Inst, N-0106 Oslo, Norway.
   AgResearch Ltd, Hamilton 3240, New Zealand.
C2 NATL RES COUNCIL CANADA, CANADA
   INST MARINE, IRELAND
   COMMISS EUROPEAN COMMUNITIES, BELGIUM
   NATL VET INST, NORWAY
   AGRESEARCH LTD, NEW ZEALAND
SI NANTES
SE PDG-ODE-LITTORAL-PHYC
IF 3.778
TC 6
UR https://archimer.ifremer.fr/doc/00037/14826/12237.pdf
LA English
DT Article
DE ;CRM-FDMT1;Certified reference material;Shellfish toxins;Phycotoxins;Accuracy;Precision;Liquid chromatography-mass spectrometry
AB The development of multi-analyte methods for lipophilic shellfish toxins based on liquid chromatography-mass spectrometry permits rapid screening and analysis of samples for a wide variety of toxins in a single run. Validated methods and appropriate certified reference materials (CRMs) are required to ensure accuracy of results. CRMs are essential for accurate instrument calibration, for assessing the complete analytical method from sample extraction to data analysis and for verifying trueness. However, CRMs have hitherto only been available for single toxin groups. Production of a CRM containing six major toxin groups was achieved through an international collaboration. Preparation of this material, CRM-FDMT1, drew on information from earlier studies as well as improved methods for isolation of toxins, handling bulk tissues and production of reference materials. Previous investigations of stabilisation techniques indicated freeze-drying to be a suitable procedure for preparation of shellfish toxin reference materials and applicable to a wide range of toxins. CRM-FDMT1 was initially prepared as a bulk wet tissue homogenate containing domoic acid, okadaic acid, dinophysistoxins, azaspiracids, pectenotoxin-2, yessotoxin and 13-desmethylspirolide C. The homogenate was then freeze-dried, milled and bottled in aliquots suitable for distribution and analysis. The moisture content and particle size distribution were measured, and determined to be appropriate. A preliminary toxin analysis of the final material showed a comprehensive toxin profile.
PY 2011
PD MAY
SO Analytical And Bioanalytical Chemistry
SN 1618-2642
PU Springer Heidelberg
VL 400
IS 3
UT 000289297000026
BP 821
EP 833
DI 10.1007/s00216-011-4786-9
ID 14826
ER

EF