First Evidence of Palytoxin and 42-Hydroxy-palytoxin in the Marine Cyanobacterium Trichodesmium

Type Article
Date 2011-04
Language English
Author(s) Kerbrat Anne Sophie1, 2, Amzil Zouher3, Pawlowiez Ralph4, Golubic Stjepko5, Sibat ManoellaORCID3, Darius Helene Taiana4, Chinain Mireille4, Laurent Dominique1, 6
Affiliation(s) 1 : Toulouse Univ, UPS, UPS IRD PHARMA DEV UMR152, F-31062 Toulouse 9, France
2 : IRD, UMR152, Noumea 98848, New Caledonia
3 : IFREMER, Lab Phycotoxins, F-44311 Nantes 3, France
4 : ILM, LMT, Papeete 98713, Tahiti, Fr Polynesia
5 : Boston Univ, Ctr Biol Sci, Boston, MA 02215 USA
6 : IRD, Papeete 98713, Tahiti, Fr Polynesia
Source Marine Drugs (1660-3397) (Mdpi Ag), 2011-04 , Vol. 9 , N. 4 , P. 543-560
DOI 10.3390/md9040543
WOS© Times Cited 56
Keyword(s) cyanobacteria, Trichodesmium, palytoxin, 42-hydroxy-palytoxin, clupeotoxism
Abstract Marine pelagic diazotrophic cyanobacteria of the genus Trichodesmium (Oscillatoriales) are widespread throughout the tropics and subtropics, and are particularly common in the waters of New Caledonia. Blooms of Trichodesmium are suspected to be a potential source of toxins in the ciguatera food chain and were previously reported to contain several types of paralyzing toxins. The toxicity of water-soluble extracts of Trichodesmium spp. were analyzed by mouse bioassay and Neuroblastoma assay and their toxic compounds characterized using liquid chromatography coupled with tandem mass spectrometry techniques. Here, we report the first identification of palytoxin and one of its derivatives, 42-hydroxy-palytoxin, in field samples of Trichodesmium collected in the New Caledonian lagoon. The possible role played by Trichodesmium blooms in the development of clupeotoxism, this human intoxication following the ingestion of plankton-eating fish and classically associated with Ostreopsis blooms, is also discussed.
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Kerbrat Anne Sophie, Amzil Zouher, Pawlowiez Ralph, Golubic Stjepko, Sibat Manoella, Darius Helene Taiana, Chinain Mireille, Laurent Dominique (2011). First Evidence of Palytoxin and 42-Hydroxy-palytoxin in the Marine Cyanobacterium Trichodesmium. Marine Drugs, 9(4), 543-560. Publisher's official version : https://doi.org/10.3390/md9040543 , Open Access version : https://archimer.ifremer.fr/doc/00040/15143/