TY - JOUR T1 - Marine Polysaccharides: A Source of Bioactive Molecules for Cell Therapy and Tissue Engineering A1 - Senni,Karim A1 - Pereira,Jessica A1 - Gueniche,Farida A1 - Delbarre-Ladrat,Christine A1 - Sinquin,Corinne A1 - Ratiskol,Jacqueline A1 - Godeau,Gaston A1 - Fischer,Anne-Marie A1 - Helley,Dominique A1 - Colliec-Jouault,Sylvia AD - IFREMER, Lab Biotechnol & Marine Mol, F-44311 Nantes 03, France. AD - Seadev FermenSys SAS, F-29280 Plouzane, France. AD - Univ Paris 05, UMR S765, Fac Pharm, INSERM,U765, F-75006 Paris, France. AD - Paris Descartes Univ, Dept Biochem, Fac Dent Surg, F-92120 Montrouge, France. AD - Hop Europeen Georges Pompidou, AP HP, Biol Hematol Dept, F-75015 Paris, France. UR - https://archimer.ifremer.fr/doc/00048/15894/ DO - 10.3390/md9091664 KW - marine bacteria KW - marine algae KW - exopolysaccharides KW - sulfated polysaccharides KW - structure KW - chemical modification KW - biological activity KW - blue biotechnology KW - cell therapy KW - tissue engineering N2 - The therapeutic potential of natural bioactive compounds such as polysaccharides, especially glycosaminoglycans, is now well documented, and this activity combined with natural biodiversity will allow the development of a new generation of therapeutics. Advances in our understanding of the biosynthesis, structure and function of complex glycans from mammalian origin have shown the crucial role of this class of molecules to modulate disease processes and the importance of a deeper knowledge of structure-activity relationships. Marine environment offers a tremendous biodiversity and original polysaccharides have been discovered presenting a great chemical diversity that is largely species specific. The study of the biological properties of the polysaccharides from marine eukaryotes and marine prokaryotes revealed that the polysaccharides from the marine environment could provide a valid alternative to traditional polysaccharides such as glycosaminoglycans. Marine polysaccharides present a real potential for natural product drug discovery and for the delivery of new marine derived products for therapeutic applications. Y1 - 2011/09 PB - Mdpi Ag JF - Marine Drugs SN - 1660-3397 VL - 9 IS - 9 SP - 1664 EP - 1681 ID - 15894 ER -