FN Archimer Export Format PT J TI Marine Polysaccharides: A Source of Bioactive Molecules for Cell Therapy and Tissue Engineering BT AF SENNI, Karim PEREIRA, Jessica GUENICHE, Farida DELBARRE-LADRAT, Christine SINQUIN, Corinne RATISKOL, Jacqueline GODEAU, Gaston FISCHER, Anne-Marie HELLEY, Dominique COLLIEC-JOUAULT, Sylvia AS 1:2;2:3;3:4;4:1;5:1;6:1;7:4;8:3,5;9:3,5;10:1; FF 1:;2:;3:;4:PDG-RBE-BRM-BMM;5:PDG-RBE-BRM-BMM;6:PDG-RBE-BRM-BMM;7:;8:;9:;10:PDG-RBE-BRM-BMM; C1 IFREMER, Lab Biotechnol & Marine Mol, F-44311 Nantes 03, France. Seadev FermenSys SAS, F-29280 Plouzane, France. Univ Paris 05, UMR S765, Fac Pharm, INSERM,U765, F-75006 Paris, France. Paris Descartes Univ, Dept Biochem, Fac Dent Surg, F-92120 Montrouge, France. Hop Europeen Georges Pompidou, AP HP, Biol Hematol Dept, F-75015 Paris, France. C2 IFREMER, FRANCE SEADEV FERMENSYS SAS, FRANCE UNIV PARIS 05, FRANCE UNIV PARIS 05, FRANCE HOP EUROPEEN GEORGES POMPIDOU, FRANCE SI BREST NANTES UNIV-FRANCAISE SE AUTRE PDG-RBE-BRM-BMM UNIV-FRANCAISE IN WOS Ifremer jusqu'en 2018 copubli-france copubli-univ-france IF 3.854 TC 144 UR https://archimer.ifremer.fr/doc/00048/15894/13316.pdf LA English DT Article DE ;marine bacteria;marine algae;exopolysaccharides;sulfated polysaccharides;structure;chemical modification;biological activity;blue biotechnology;cell therapy;tissue engineering AB The therapeutic potential of natural bioactive compounds such as polysaccharides, especially glycosaminoglycans, is now well documented, and this activity combined with natural biodiversity will allow the development of a new generation of therapeutics. Advances in our understanding of the biosynthesis, structure and function of complex glycans from mammalian origin have shown the crucial role of this class of molecules to modulate disease processes and the importance of a deeper knowledge of structure-activity relationships. Marine environment offers a tremendous biodiversity and original polysaccharides have been discovered presenting a great chemical diversity that is largely species specific. The study of the biological properties of the polysaccharides from marine eukaryotes and marine prokaryotes revealed that the polysaccharides from the marine environment could provide a valid alternative to traditional polysaccharides such as glycosaminoglycans. Marine polysaccharides present a real potential for natural product drug discovery and for the delivery of new marine derived products for therapeutic applications. PY 2011 PD SEP SO Marine Drugs SN 1660-3397 PU Mdpi Ag VL 9 IS 9 UT 000298927500015 BP 1664 EP 1681 DI 10.3390/md9091664 ID 15894 ER EF