Modelling of paralytic shellfish toxin biotransformations in the course of Crassostrea gigas detoxification kinetics

Type Article
Date 2011-09
Language English
Author(s) Gueguen Marielle2, Baron RegisORCID1, Bardouil Michele3, Truquet Philippe3, Haberkorn Hansy4, Lassus Patrick3, Barille Laurent5, Amzil Zouher3
Affiliation(s) 1 : IFREMER, Lab Sci & Technol Biomasse Marine, F-44311 Nantes, France.
2 : Univ Caen, Microbiol Interet Laitier & Alimentaire EA 3214, F-14032 Caen, France.
3 : IFREMER, Lab Phycotoxines, F-44311 Nantes, France.
4 : Univ Bretagne Occidentale, Lab Sci Environm Marin, Inst Univ Europeen Mer, F-29280 Plouzane, France.
5 : Univ Nantes, F-44322 Nantes 3, France.
Source Ecological Modelling (0304-3800) (Elsevier Science Bv), 2011-09 , Vol. 222 , N. 18 , P. 3394-3402
DOI 10.1016/j.ecolmodel.2011.07.007
WOS© Times Cited 11
Keyword(s) Detoxification kinetics modelling, Biotransformation of saxitoxin analogues, Oyster
Abstract The aim of this study was to evaluate the importance of biotransformation of paralytic shellfish toxins during the detoxification process in contaminated oysters. Mathematical models based upon the detoxification patterns of digestive gland and other tissues were developed. It was demonstrated that biotransformations do not seem to play an important role in digestive gland or other tissue detoxification kinetics with our data set. Moreover, different toxin transfers from digestive gland toward other tissues were investigated. No significant transfer was highlighted in our data set. These first conclusions were drawn after comparing the results obtained from 13 biotransformations and identifiable transfer scenarios. Finally, to determine a more robust model, all 12 states corresponding to toxic compounds and tissues were aggregated into a single state model. The best adjustment was obtained with a simple one-compartment model based on total flesh toxicity with elimination rate expressed by a function depending on initial concentrations of GTX3 and GTX2 (i.e. the two major toxic compounds found in contaminated oysters). (C) 2011 Elsevier B.V. All rights reserved.
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Gueguen Marielle, Baron Regis, Bardouil Michele, Truquet Philippe, Haberkorn Hansy, Lassus Patrick, Barille Laurent, Amzil Zouher (2011). Modelling of paralytic shellfish toxin biotransformations in the course of Crassostrea gigas detoxification kinetics. Ecological Modelling, 222(18), 3394-3402. Publisher's official version : https://doi.org/10.1016/j.ecolmodel.2011.07.007 , Open Access version : https://archimer.ifremer.fr/doc/00049/16047/