FN Archimer Export Format
PT J
TI Modelling of paralytic shellfish toxin biotransformations in the course of Crassostrea gigas detoxification kinetics
BT 
AF GUEGUEN, Marielle
   BARON, Regis
   BARDOUIL, Michele
   TRUQUET, Philippe
   HABERKORN, Hansy
   LASSUS, Patrick
   BARILLE, Laurent
   AMZIL, Zouher
AS 1:2;2:1;3:3;4:3;5:4;6:3;7:5;8:3;
FF 1:;2:PDG-RBE-BRM-STBM;3:PDG-RBE-EMP-PHYC;4:PDG-RBE-EMP-PHYC;5:;6:PDG-RBE-EMP-PHYC;7:;8:PDG-RBE-EMP-PHYC;
C1 IFREMER, Lab Sci & Technol Biomasse Marine, F-44311 Nantes, France.
   Univ Caen, Microbiol Interet Laitier & Alimentaire EA 3214, F-14032 Caen, France.
   IFREMER, Lab Phycotoxines, F-44311 Nantes, France.
   Univ Bretagne Occidentale, Lab Sci Environm Marin, Inst Univ Europeen Mer, F-29280 Plouzane, France.
   Univ Nantes, F-44322 Nantes 3, France.
C2 IFREMER, FRANCE
   UNIV CAEN, FRANCE
   IFREMER, FRANCE
   UBO, FRANCE
   UNIV NANTES, FRANCE
SI NANTES
SE PDG-RBE-BRM-STBM
   PDG-RBE-EMP-PHYC
IN WOS Ifremer jusqu'en 2018
   copubli-france
   copubli-univ-france
IF 2.326
TC 14
UR https://archimer.ifremer.fr/doc/00049/16047/14309.pdf
LA English
DT Article
DE ;Detoxification kinetics modelling;Biotransformation of saxitoxin analogues;Oyster
AB The aim of this study was to evaluate the importance of biotransformation of paralytic shellfish toxins during the detoxification process in contaminated oysters. Mathematical models based upon the detoxification patterns of digestive gland and other tissues were developed. It was demonstrated that biotransformations do not seem to play an important role in digestive gland or other tissue detoxification kinetics with our data set. Moreover, different toxin transfers from digestive gland toward other tissues were investigated. No significant transfer was highlighted in our data set. These first conclusions were drawn after comparing the results obtained from 13 biotransformations and identifiable transfer scenarios. Finally, to determine a more robust model, all 12 states corresponding to toxic compounds and tissues were aggregated into a single state model. The best adjustment was obtained with a simple one-compartment model based on total flesh toxicity with elimination rate expressed by a function depending on initial concentrations of GTX3 and GTX2 (i.e. the two major toxic compounds found in contaminated oysters). (C) 2011 Elsevier B.V. All rights reserved.
PY 2011
PD SEP
SO Ecological Modelling
SN 0304-3800
PU Elsevier Science Bv
VL 222
IS 18
UT 000296124400008
BP 3394
EP 3402
DI 10.1016/j.ecolmodel.2011.07.007
ID 16047
ER

EF