FN Archimer Export Format
PT J
TI Effects of low-dose exposure to pesticide mixture on physiological responses of the pacific oyster, Crassostrea gigas
BT 
AF GERET, Florence
   BURGEOT, Thierry
   HAURE, Joel
   GAGNAIRE, Beatrice
   RENAULT, Tristan
   COMMUNAL, Pierre-Yves
   SAMAIN, Jean-Francois
AS 1:1;2:2;3:3;4:4;5:5;6:6;7:7;
FF 1:;2:PDG-RBE-BE;3:PDG-RBE-SG2M-LSEM;4:;5:PDG-RBE-SG2M;6:;7:PDG-RBE-PFOM-PI;
C1 Univ Toulouse, GEODE, CNRS, Ctr Univ Albi,UMR 5602, F-81012 Albi, France.
   IFREMER, Ecotoxicol Lab, F-44311 Nantes, France.
   IFREMER, Shellfish Farming Lab, F-85230 Bouin, France.
   Inst Radioprotect & Nucl Safety IRSN, DEI SECRE LRE, Lab Radioecol & Ecotoxicol, F-13115 St Paul Les Durance 13115, France.
   Ifremer LGP Genet & Pathol Lab, F-17380 La Tremblade, France.
   Univ Angers, Lab Sci & Environm, F-49000 Angers, France.
   IFREMER, UMR 100 Physiol & Ecophysiol Marine Molluscs, F-29280 Plouzane, France.
C2 UNIV TOULOUSE, FRANCE
   IFREMER, FRANCE
   IFREMER, FRANCE
   IRSN, FRANCE
   IFREMER, FRANCE
   UNIV ANGERS, FRANCE
   IFREMER, FRANCE
SI NANTES
   LA TREMBLADE
   AUTRE
   BREST
SE PDG-RBE-BE
   PDG-RBE-SG2M-LSEM
   PDG-RBE-SG2M
   AUTRE
   PDG-RBE-PFOM-PI
IN WOS Ifremer jusqu'en 2018
   copubli-france
   copubli-univ-france
IF 2.562
TC 26
UR https://archimer.ifremer.fr/doc/00065/17641/88201.pdf
LA English
DT Article
DE ;pesticides;oyster;immunotoxicity;catalase;glutathione S-transferase;glutamine synthetase;DNA adducts
AB This study investigated the effects on the physiology of Pacific oyster, Crassostrea gigas, of a mixture of pesticides containing 0.8 μg L−1 alachlor, 0.6 μg L−1 metolachlor, 0.7 μg L−1 atrazine, 0.6 μg L−1 terbuthylazine, 0.5 μg L−1 diuron, 0.6 μg L−1 fosetyl aluminum, 0.05 μg L−1 carbaryl, and 0.7 μg L−1 glyphosate for a total concentration of 4.55 μg L−1. The total nominal concentration of pesticides mixture corresponds to the pesticide concentrations in the shellfish culture area of the Marennes-Oleron basin. Two varieties of C. gigas were selected on the foreshore, based on their characteristics in terms of resistance to summer mortality, to assess the effects of the pesticide mixture after 7 days of exposure under controlled conditions. The early effects of the mixture were assessed using enzyme biomarkers of nitrogen metabolism (GS, glutamine synthetase), detoxification metabolism (GST, glutathione S-transferase), and oxidative stress (CAT, catalase). Sublethal effects on hemocyte parameters (phagocytosis and esterase activity) and DNA damages (DNA adducts) were also measured. Changes in metabolic activities were characterized by increases in GS, GST, and CAT levels on the first day of exposure for the “resistant” oysters and after 3–7 days of exposure for the “susceptible” oysters. The formation of DNA adducts was detected after 7 days of exposure. The percentage of hemocyte esterase-positive cells was reduced in the resistant oysters, as was the hemocyte phagocytic capacity in both oyster varieties after 7 days of exposure to the pesticide mixture. This study highlights the need to consider the low doses and the mixture of pesticides to evaluate the effects of these molecules on organisms. © 2011 Wiley Periodicals, Inc. Environ Toxicol, 2011.
PY 2013
PD DEC
SO Environmental Toxicology
SN 1520-4081
PU Wiley-blackwell
VL 28
IS 12
UT 000326706600005
BP 689
EP 699
DI 10.1002/tox.20764
ID 17641
ER

EF