Expression, tissue localization and synergy of antimicrobial peptides and proteins in the immune response of the oyster Crassostrea gigas

Type Article
Date 2012-07
Language English
Author(s) Schmitt Paulina1, 2, de Lorgeril JulienORCID1, Gueguen YannickORCID1, Destoumieux-Garzon Delphine3, 4, Bachere Evelyne1
Affiliation(s) 1 : IFREMER, Ecol Syst Marins Cotiers UMR5119, F-34095 Montpellier 5, France.
2 : Univ Montpellier 2, Ecol Syst Marins Cotiers UMR5119, F-34095 Montpellier 5, France.
3 : Univ Montpellier I, Ecol Syst Marins Cotiers UMR5119, F-34095 Montpellier 5, France.
4 : CNRS, IRD, F-34095 Montpellier 5, France.
Source Developmental And Comparative Immunology (0145-305X) (Elsevier Sci Ltd), 2012-07 , Vol. 37 , N. 3-4 , P. 363-370
DOI 10.1016/j.dci.2012.01.004
WOS© Times Cited 42
Keyword(s) Pacific oyster, Bivalve mollusk, Innate immunity, Bactericidal/permeability-increasing protein, Proline-rich peptide, Defensin, Vibrio
Abstract Diverse families of antimicrobial peptides and proteins have been described in oysters. We investigated here how antimicrobials are involved in the immune response against a pathogenic strain of Vibrio splendidus. Oyster antimicrobials were shown to display a wide variety of expression profiles in hemocyte populations and tissues. Oyster defensins are constitutively expressed in specific tissues such as mantle (Cg-Defm) or hemocytes (Cg-Defhs), while Cg-BPI is inducible and Cg-Prp appears down-regulated in hemocytes upon infection. The migratory behavior of hemocytes that express the different antimicrobials was found to be involved in the oyster response to a pathogenic Vibrio infection. Indeed, it contributes to colocalize several antimicrobials that were shown here to have synergistic activities. We propose that such a synergy, which was evidenced both within and between families of antimicrobials, might compensate for the low concentration of antimicrobials in oyster tissues. (c) 2012 Elsevier Ltd. All rights reserved.
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Schmitt Paulina, de Lorgeril Julien, Gueguen Yannick, Destoumieux-Garzon Delphine, Bachere Evelyne (2012). Expression, tissue localization and synergy of antimicrobial peptides and proteins in the immune response of the oyster Crassostrea gigas. Developmental And Comparative Immunology, 37(3-4), 363-370. Publisher's official version : https://doi.org/10.1016/j.dci.2012.01.004 , Open Access version : https://archimer.ifremer.fr/doc/00093/20382/