FN Archimer Export Format
PT J
TI Expression, tissue localization and synergy of antimicrobial peptides and proteins in the immune response of the oyster Crassostrea gigas
BT 
AF SCHMITT, Paulina
   DE LORGERIL, Julien
   GUEGUEN, Yannick
   DESTOUMIEUX-GARZON, Delphine
   BACHERE, Evelyne
AS 1:1,2;2:1;3:1;4:3,4;5:1;
FF 1:PDG-RBE-BOME-LALR;2:PDG-RBE-BOME-LALR;3:PDG-RBE-RMPF-EP;4:;5:PDG-RBE-BOME;
C1 IFREMER, Ecol Syst Marins Cotiers UMR5119, F-34095 Montpellier 5, France.
   Univ Montpellier 2, Ecol Syst Marins Cotiers UMR5119, F-34095 Montpellier 5, France.
   Univ Montpellier I, Ecol Syst Marins Cotiers UMR5119, F-34095 Montpellier 5, France.
   CNRS, IRD, F-34095 Montpellier 5, France.
C2 IFREMER, FRANCE
   UNIV MONTPELLIER, FRANCE
   UNIV MONTPELLIER, FRANCE
   CNRS, FRANCE
SI MONTPELLIER
   TAHITI
   PALAVAS
SE PDG-RBE-BOME-LALR
   PDG-RBE-RMPF-EP
   PDG-RBE-BOME
IN WOS Ifremer jusqu'en 2018
   copubli-france
   copubli-univ-france
IF 3.24
TC 42
UR https://archimer.ifremer.fr/doc/00093/20382/18267.pdf
LA English
DT Article
DE ;Pacific oyster;Bivalve mollusk;Innate immunity;Bactericidal/permeability-increasing protein;Proline-rich peptide;Defensin;Vibrio
AB Diverse families of antimicrobial peptides and proteins have been described in oysters. We investigated here how antimicrobials are involved in the immune response against a pathogenic strain of Vibrio splendidus. Oyster antimicrobials were shown to display a wide variety of expression profiles in hemocyte populations and tissues. Oyster defensins are constitutively expressed in specific tissues such as mantle (Cg-Defm) or hemocytes (Cg-Defhs), while Cg-BPI is inducible and Cg-Prp appears down-regulated in hemocytes upon infection. The migratory behavior of hemocytes that express the different antimicrobials was found to be involved in the oyster response to a pathogenic Vibrio infection. Indeed, it contributes to colocalize several antimicrobials that were shown here to have synergistic activities. We propose that such a synergy, which was evidenced both within and between families of antimicrobials, might compensate for the low concentration of antimicrobials in oyster tissues. (c) 2012 Elsevier Ltd. All rights reserved.
PY 2012
PD JUN
SO Developmental And Comparative Immunology
SN 0145-305X
PU Elsevier Sci Ltd
VL 37
IS 3-4
UT 000306891500006
BP 363
EP 370
DI 10.1016/j.dci.2012.01.004
ID 20382
ER

EF