Insights into the antiviral functions of the RNAi machinery in penaeid shrimp

Type Article
Date 2013-04
Language English
Author(s) Labreuche Yannick1, Warr Gregory W.2, 3
Affiliation(s) 1 : IFREMER, Dept Lagons Ecosyst & Aquaculture Durable Nouvell, Noumea 98846, New Caledonia.
2 : Natl Sci Fdn, Div Mol & Cellular Biosci, Arlington, VA 22230 USA.
3 : Med Univ S Carolina, Dept Biochem & Mol Biol, Charleston, SC 29425 USA.
Source Fish & Shellfish Immunology (1050-4648) (Academic Press Ltd- Elsevier Science Ltd), 2013-04 , Vol. 34 , N. 4 , P. 1002-1010
DOI 10.1016/j.fsi.2012.06.008
WOS© Times Cited 22
Keyword(s) Shrimp, Innate immune response, In vertebrate immunity, RNA interference, Virus
Abstract Over the last decade, RNA interference pathways have emerged in eukaryotes as critical regulators of many diverse biological functions including, among others, transcriptional gene regulation, post-transcriptional gene silencing, heterochromatin remodelling, suppression of transposon activity, and antiviral defences. Although this gene silencing process has been reported to be relatively well conserved in species of different phyla, there are important discrepancies between plants, invertebrates and mammals. In penaeid shrimp, the existence of an intact and functional RNAi machinery is supported by a rapidly growing body of evidence. However, the extent to which this process participates to the host immune responses remains poorly defined in this non-model organism. This review summarizes our current knowledge of RNAi mechanisms in shrimp and focuses on their implication in antiviral activities and shrimp immune defences.
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