FN Archimer Export Format
PT CHAP
TI Heparin-like Entities from Marine Organisms
BT Heparin - A Century of Progress. R. Lever et al. (eds.). 2012 . Handbook of Experimental Pharmacology 207. pp.423-449
AF COLLIEC-JOUAULT, Sylvia
   BAVINGTON, C.
   DELBARRE-LADRAT, Christine
AS 1:1;2:2;3:1;
FF 1:PDG-RBE-BRM-BMM;2:;3:PDG-RBE-BRM-BMM;
C1 Laboratoire de Biotechnologie et Molécules Marines, Ifremer, Rue de l’Ile d’Yeu, 21105, 44311, Nantes Cedex 3, France
   Dunstfaffnage Marine Laboratory, Glycomar Ltd, European Centre for Marine Biotechnology, Dunbeg, Oban, Argyll, PA37 1QA, UK
C2 IFREMER, FRANCE
   ECMB, UK
SI NANTES
SE PDG-RBE-BRM-BMM
UR https://archimer.ifremer.fr/doc/00127/23874/21850.pdf
LA English
DT Book section
AB Polysaccharides are ubiquitous in animals and plant cells where they play a significant role in a number of physiological situations e.g. hydration, mechanical properties of cell walls and ionic regulation. This review concentrates on heparin-like entities from marine procaryotes and eukaryotes. Carbohydrates from marine prokaryotes offer a significant structural chemodiversity with novel material and biological properties. Cyanobacteria are Gram-negative photosynthetic prokaryotes considered as a rich source of novel molecules, and marine bacteria are a rich source of polysaccharides with novel structures, which may be a good starting point from which to synthesise heparinoid molecules. For example, some sulphated polysaccharides have been isolated from gamma-proteobacteria such as Alteromonas and Pseudoalteromonas sp. In contrast to marine bacteria, all marine algae contain sulphated wall polysaccharides, whereas such polymers are not found in terrestrial plants. In their native form, or after chemical modifications, a range of polysaccharides isolated from marine organisms have been described that have anticoagulant, anti-thrombotic, anti-tumour, anti-proliferative, anti-viral or anti-inflammatory activities.  In spite of the enormous potential of sulphated oligosaccharides from marine sources, their technical and pharmaceutical usage is still limited because of the high complexity of these molecules. Thus, the production of tailor-made oligo- and polysaccharidic structures by biocatalysis is also a growing field of interest in biotechnology.
PY 2012
DI 10.1007/978-3-642-23056-1_19
ID 23874
ER

EF