Complete genome sequence of acute viral necrosis virus associated with massive mortality outbreaks in the Chinese scallop, Chlamys farreri
| Type | Article | ||||||||
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| Date | 2013-04 | ||||||||
| Language | English | ||||||||
| Author(s) | Ren Weicheng, Chen Haixia, Renault Tristan, Cai Yuyong, Bai Changming, Wang Chongming, Huang Jie | ||||||||
| Affiliation(s) | Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Maricultural Organism Dis Control & Pathogen Mol, Qingdao 266071, Peoples R China. Univ Gothenburg, Dept Rheumatol & Inflammat, S-40530 Gothenburg, Sweden. Univ Gothenburg, Dept Biol & Environm Sci, S-40530 Gothenburg, Sweden. Ifremer, Unite Sante Genet & Microgiol Mollusques, Lab Genet & Pathol Mollusques Marins, F-17390 La Tremblade, France. |
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| Source | Virology Journal (1743-422X) (Biomed Central Ltd), 2013-04 , Vol. 10 , P. - | ||||||||
| DOI | 10.1186/1743-422X-10-110 | ||||||||
| WOS© Times Cited | 59 | ||||||||
| Keyword(s) | Acute viral necrosis virus (AVNV), Herpesvirus, OsHV-1, Genome | ||||||||
| Abstract | Acute viral necrosis virus (AVNV) is the causative agent of a serious disease resulting in high mortality in cultured Chinese scallops, Chlamys farreri. We have sequenced and analyzed the complete genome of AVNV. The AVNV genome is a linear, double-stranded DNA molecule of 210,993 bp with a nucleotide composition of 38.5% G + C. A total of 123 open reading frames were predicted to encode functional proteins, ranging from 41 to 1,878 amino acid residues. The DNA sequence of AVNV is 97% identical to that of ostreid herpesvirus 1 (OsHV-1), and the amino acid sequences of the encoded proteins of these two viruses are 94-100% identical. The genomic organization of AVNV is similar to that of OsHV-1, and consists of two unique regions (170.4 kb and 3.4 kb, respectively), each flanked by two inverted repeats (7.6 kb and 10.2 kb, respectively), with a third unique region (1.5 kb) situated between the two internal repeats. Our results indicate that AVNV is a variant of OsHV-1. The AVNV genome sequence provides information useful for understanding the evolution and divergence of OsHV-1 in marine molluscs. | ||||||||
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