FN Archimer Export Format PT J TI Complete genome sequence of acute viral necrosis virus associated with massive mortality outbreaks in the Chinese scallop, Chlamys farreri BT AF REN, Weicheng CHEN, Haixia RENAULT, Tristan CAI, Yuyong BAI, Changming WANG, Chongming HUANG, Jie AS 1:;2:;3:;4:;5:;6:;7:; FF 1:;2:;3:PDG-RBE-SG2M;4:;5:;6:;7:; C1 Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Maricultural Organism Dis Control & Pathogen Mol, Qingdao 266071, Peoples R China. Univ Gothenburg, Dept Rheumatol & Inflammat, S-40530 Gothenburg, Sweden. Univ Gothenburg, Dept Biol & Environm Sci, S-40530 Gothenburg, Sweden. Ifremer, Unite Sante Genet & Microgiol Mollusques, Lab Genet & Pathol Mollusques Marins, F-17390 La Tremblade, France. C2 CHINESE ACAD FISHERY SCI, CHINA UNIV GOTHENBURG, SWEDEN UNIV GOTHENBURG, SWEDEN IFREMER, FRANCE SI LA TREMBLADE SE PDG-RBE-SG2M IN WOS Ifremer jusqu'en 2018 copubli-europe copubli-int-hors-europe copubli-sud IF 2.089 TC 59 UR https://archimer.ifremer.fr/doc/00135/24620/22650.pdf LA English DT Article DE ;Acute viral necrosis virus (AVNV);Herpesvirus;OsHV-1;Genome AB Acute viral necrosis virus (AVNV) is the causative agent of a serious disease resulting in high mortality in cultured Chinese scallops, Chlamys farreri. We have sequenced and analyzed the complete genome of AVNV. The AVNV genome is a linear, double-stranded DNA molecule of 210,993 bp with a nucleotide composition of 38.5% G + C. A total of 123 open reading frames were predicted to encode functional proteins, ranging from 41 to 1,878 amino acid residues. The DNA sequence of AVNV is 97% identical to that of ostreid herpesvirus 1 (OsHV-1), and the amino acid sequences of the encoded proteins of these two viruses are 94-100% identical. The genomic organization of AVNV is similar to that of OsHV-1, and consists of two unique regions (170.4 kb and 3.4 kb, respectively), each flanked by two inverted repeats (7.6 kb and 10.2 kb, respectively), with a third unique region (1.5 kb) situated between the two internal repeats. Our results indicate that AVNV is a variant of OsHV-1. The AVNV genome sequence provides information useful for understanding the evolution and divergence of OsHV-1 in marine molluscs. PY 2013 PD APR SO Virology Journal SN 1743-422X PU Biomed Central Ltd VL 10 UT 000317657000001 DI 10.1186/1743-422X-10-110 ID 24620 ER EF