FN Archimer Export Format
PT J
TI The impact of insecticide resistance on Culex pipiens immunity
BT 
AF VEZILIER, Julien
   NICOT, Antoine
   DE LORGERIL, Julien
   GANDON, Sylvain
   RIVERO, Ana
AS 1:1;2:1,3;3:2;4:3;5:1;
FF 1:;2:;3:PDG-RBE-BOME-LALR;4:;5:;
C1 IRD, MIVEGEC, CNRS, Ctr Rech,UMR 5290, F-34394 Montpellier, France.
   Univ Montpellier 2, IFREMER, CNRS, IRD, Montpellier, France.
   Univ Montpellier I, UMR 5519, Lab Ecol Syst Marins Cotiers, Montpellier, France.
   CNRS, Ctr Ecol Fonct & Evolut, UMR 5175, F-34033 Montpellier, France.
C2 IRD, FRANCE
   IFREMER, FRANCE
   UNIV MONTPELLIER, FRANCE
   CNRS, FRANCE
SI MONTPELLIER
SE PDG-RBE-BOME-LALR
IN WOS Ifremer jusqu'en 2018
   copubli-france
   copubli-p187
   copubli-univ-france
IF 4.569
TC 22
UR https://archimer.ifremer.fr/doc/00136/24773/22845.pdf
LA English
DT Article
DE ;acetylcholinesterase;anopheles;antimicrobial peptide;carboxylesterases;nitric oxide;transferrin
AB Because of their role as vectors of diseases, the evolution of insecticide resistance in mosquitoes has been intensively investigated. Insecticide resistance is associated to a wide range of pleiotropic effects on several key life-history traits of mosquitoes such as longevity and behavior. However, despite its potential implications in pathogen transmission, the effects of insecticide resistance on mosquito immunity have received little, if any, attention. Here, we investigate the impact of insecticide resistance in Culex pipiens, an epidemiologically important vector of a wide array of pathogens. Using both isogenic laboratory strains and field-caught mosquitoes, we investigate the impact of two main insecticide resistance mechanisms (metabolic detoxification and target site modification) on the relative transcription of several genes involved in the immune response to pathogens, at both their constitutive and inducible levels. Our results show a discrepancy between the isogenic laboratory lines and field-collected mosquitoes: While in the isogenic strains, insecticide-resistant mosquitoes show a drastic increase in immune gene expression, no such effect appears in the field. We speculate on the different mechanisms that may underlie this discrepancy and discuss the risks of making inferences on the pleiotropic effects of insecticide-resistant genes by using laboratory-selected insecticide-resistant lines.
PY 2013
PD APR
SO Evolutionary Applications
SN 1752-4571
PU Wiley-blackwell
VL 6
IS 3
UT 000316957800009
BP 497
EP 509
DI 10.1111/eva.12037
ID 24773
ER

EF