FN Archimer Export Format PT J TI A novel "Integrated Biomarker Response" calculation based on reference deviation concept BT AF SANCHEZ, Wilfried BURGEOT, Thierry PORCHER, Jean-Marc AS 1:1;2:2;3:1; FF 1:;2:PDG-RBE-BE;3:; C1 Inst Natl Environm Ind & Risques INERIS, Unite Ecotoxicol In Vitro & In Vivo, F-60550 Verneuil En Halatte, France. Inst Francais Rech Exploitat Mer IFREMER, Unite Ecotoxicol, F-44311 Nantes 3, France. C2 INERIS, FRANCE IFREMER, FRANCE SI NANTES SE PDG-RBE-BE IN WOS Ifremer jusqu'en 2018 copubli-france IF 2.757 TC 198 UR https://archimer.ifremer.fr/doc/00139/25069/23191.pdf LA English DT Article DE ;Biomarkers;Data analysis;Graphic tools;Three-spined stickleback AB Multi-biomarker approaches are used to assess ecosystem health and identify impacts of environmental stress on organisms. However, exploration of large datasets by environmental managers represents a major challenge for regulatory application of this tool. Several integrative tools were developed to summarize biomarker responses. The aim of the present paper is to update calculation of the "Integrated Biological Response" (IBR) described by Beliaeff and Burgeot (Environ Toxicol Chem 21:1316-1322, 2002) to avoid weaknesses of this integrative tool. In the present paper, a novel index named "Integrated Biological Responses version 2" based on the reference deviation concept is presented. It allows a clear discrimination of sampling sites as for the IBR, but several differences are observed for contaminated sites according to up- and downregulation of biomarker responses. This novel tool could be used to integrate multi-biomarker responses not only in large-scale monitoring but also in upstream/downstream investigations. PY 2013 PD MAY SO Environmental Science And Pollution Research SN 0944-1344 PU Springer Heidelberg VL 20 IS 5 UT 000318175400004 BP 2721 EP 2725 DI 10.1007/s11356-012-1359-1 ID 25069 ER EF